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Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function
Metformin has been used in diabetes for more than 60 years and has excellent safety in the therapy of human type 2 diabetes (T2D). There is growing evidence that the beneficial health effects of metformin are beyond its ability to improve glucose metabolism. Metformin not only reduces the incidence...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227439/ https://www.ncbi.nlm.nih.gov/pubmed/32457625 http://dx.doi.org/10.3389/fphar.2020.00635 |
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author | Deng, Mingying Su, Dan Xu, Suowen Little, Peter J. Feng, Xiaojun Tang, Liqin Shen, Aizong |
author_facet | Deng, Mingying Su, Dan Xu, Suowen Little, Peter J. Feng, Xiaojun Tang, Liqin Shen, Aizong |
author_sort | Deng, Mingying |
collection | PubMed |
description | Metformin has been used in diabetes for more than 60 years and has excellent safety in the therapy of human type 2 diabetes (T2D). There is growing evidence that the beneficial health effects of metformin are beyond its ability to improve glucose metabolism. Metformin not only reduces the incidence of cardiovascular diseases (CVD) in T2D patients, but also reduces the burden of atherosclerosis (AS) in pre-diabetes patients. Vascular smooth muscle cells (VSMCs) function is an important factor in determining the characteristics of the entire arterial vessel. Its excessive proliferation contributes to the etiology of several types of CVD, including AS, restenosis, and pulmonary hypertension. Current studies show that metformin has a beneficial effect on VSMCs function. Therefore, this review provides a timely overview of the role and molecular mechanisms by which metformin acts through VSMCs to protect CVD. |
format | Online Article Text |
id | pubmed-7227439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72274392020-05-25 Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function Deng, Mingying Su, Dan Xu, Suowen Little, Peter J. Feng, Xiaojun Tang, Liqin Shen, Aizong Front Pharmacol Pharmacology Metformin has been used in diabetes for more than 60 years and has excellent safety in the therapy of human type 2 diabetes (T2D). There is growing evidence that the beneficial health effects of metformin are beyond its ability to improve glucose metabolism. Metformin not only reduces the incidence of cardiovascular diseases (CVD) in T2D patients, but also reduces the burden of atherosclerosis (AS) in pre-diabetes patients. Vascular smooth muscle cells (VSMCs) function is an important factor in determining the characteristics of the entire arterial vessel. Its excessive proliferation contributes to the etiology of several types of CVD, including AS, restenosis, and pulmonary hypertension. Current studies show that metformin has a beneficial effect on VSMCs function. Therefore, this review provides a timely overview of the role and molecular mechanisms by which metformin acts through VSMCs to protect CVD. Frontiers Media S.A. 2020-05-08 /pmc/articles/PMC7227439/ /pubmed/32457625 http://dx.doi.org/10.3389/fphar.2020.00635 Text en Copyright © 2020 Deng, Su, Xu, Little, Feng, Tang and Shen http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Deng, Mingying Su, Dan Xu, Suowen Little, Peter J. Feng, Xiaojun Tang, Liqin Shen, Aizong Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function |
title | Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function |
title_full | Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function |
title_fullStr | Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function |
title_full_unstemmed | Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function |
title_short | Metformin and Vascular Diseases: A Focused Review on Smooth Muscle Cell Function |
title_sort | metformin and vascular diseases: a focused review on smooth muscle cell function |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227439/ https://www.ncbi.nlm.nih.gov/pubmed/32457625 http://dx.doi.org/10.3389/fphar.2020.00635 |
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