Sleep Disturbances in MCI and AD: Neuroinflammation as a Possible Mediating Pathway

Mild cognitive impairment (MCI) and Alzheimer’s disease (AD) affect a high proportion of the elderly population with an increasing prevalence. Sleep disturbances are frequent in those with MCI and AD. This review summarizes existing research on sleep disturbances and neuroinflammation in MCI and AD....

Descripción completa

Detalles Bibliográficos
Autores principales: Pak, Victoria M., Onen, S.-Hakki, Bliwise, Donald L., Kutner, Nancy G., Russell, Katherine L., Onen, Fannie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227443/
https://www.ncbi.nlm.nih.gov/pubmed/32457592
http://dx.doi.org/10.3389/fnagi.2020.00069
_version_ 1783534502541262848
author Pak, Victoria M.
Onen, S.-Hakki
Bliwise, Donald L.
Kutner, Nancy G.
Russell, Katherine L.
Onen, Fannie
author_facet Pak, Victoria M.
Onen, S.-Hakki
Bliwise, Donald L.
Kutner, Nancy G.
Russell, Katherine L.
Onen, Fannie
author_sort Pak, Victoria M.
collection PubMed
description Mild cognitive impairment (MCI) and Alzheimer’s disease (AD) affect a high proportion of the elderly population with an increasing prevalence. Sleep disturbances are frequent in those with MCI and AD. This review summarizes existing research on sleep disturbances and neuroinflammation in MCI and AD. Although strong evidence supports various pathways linking sleep and AD pathology, the temporal direction of this central relationship is not yet known. Improved understanding of sleep disturbance and neuroinflammation in MCI and AD may aid in the identification of targets for their prevention.
format Online
Article
Text
id pubmed-7227443
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-72274432020-05-25 Sleep Disturbances in MCI and AD: Neuroinflammation as a Possible Mediating Pathway Pak, Victoria M. Onen, S.-Hakki Bliwise, Donald L. Kutner, Nancy G. Russell, Katherine L. Onen, Fannie Front Aging Neurosci Neuroscience Mild cognitive impairment (MCI) and Alzheimer’s disease (AD) affect a high proportion of the elderly population with an increasing prevalence. Sleep disturbances are frequent in those with MCI and AD. This review summarizes existing research on sleep disturbances and neuroinflammation in MCI and AD. Although strong evidence supports various pathways linking sleep and AD pathology, the temporal direction of this central relationship is not yet known. Improved understanding of sleep disturbance and neuroinflammation in MCI and AD may aid in the identification of targets for their prevention. Frontiers Media S.A. 2020-05-08 /pmc/articles/PMC7227443/ /pubmed/32457592 http://dx.doi.org/10.3389/fnagi.2020.00069 Text en Copyright © 2020 Pak, Onen, Bliwise, Kutner, Russell and Onen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Pak, Victoria M.
Onen, S.-Hakki
Bliwise, Donald L.
Kutner, Nancy G.
Russell, Katherine L.
Onen, Fannie
Sleep Disturbances in MCI and AD: Neuroinflammation as a Possible Mediating Pathway
title Sleep Disturbances in MCI and AD: Neuroinflammation as a Possible Mediating Pathway
title_full Sleep Disturbances in MCI and AD: Neuroinflammation as a Possible Mediating Pathway
title_fullStr Sleep Disturbances in MCI and AD: Neuroinflammation as a Possible Mediating Pathway
title_full_unstemmed Sleep Disturbances in MCI and AD: Neuroinflammation as a Possible Mediating Pathway
title_short Sleep Disturbances in MCI and AD: Neuroinflammation as a Possible Mediating Pathway
title_sort sleep disturbances in mci and ad: neuroinflammation as a possible mediating pathway
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227443/
https://www.ncbi.nlm.nih.gov/pubmed/32457592
http://dx.doi.org/10.3389/fnagi.2020.00069
work_keys_str_mv AT pakvictoriam sleepdisturbancesinmciandadneuroinflammationasapossiblemediatingpathway
AT onenshakki sleepdisturbancesinmciandadneuroinflammationasapossiblemediatingpathway
AT bliwisedonaldl sleepdisturbancesinmciandadneuroinflammationasapossiblemediatingpathway
AT kutnernancyg sleepdisturbancesinmciandadneuroinflammationasapossiblemediatingpathway
AT russellkatherinel sleepdisturbancesinmciandadneuroinflammationasapossiblemediatingpathway
AT onenfannie sleepdisturbancesinmciandadneuroinflammationasapossiblemediatingpathway

Ejemplares similares