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Role of Macrophages in the Progression and Regression of Vascular Calcification

Vascular calcification is an abnormal cell-mediated process in which bone-specific hydroxyapatite crystals are actively deposited on the blood vessel wall and is a significant pathological basis for the increased incidence and mortality of adverse cardiovascular events. Macrophages play an important...

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Autores principales: Li, Yalan, Sun, Zhen, Zhang, Lili, Yan, Jinchuan, Shao, Chen, Jing, Lele, Li, Lihua, Wang, Zhongqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227444/
https://www.ncbi.nlm.nih.gov/pubmed/32457633
http://dx.doi.org/10.3389/fphar.2020.00661
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author Li, Yalan
Sun, Zhen
Zhang, Lili
Yan, Jinchuan
Shao, Chen
Jing, Lele
Li, Lihua
Wang, Zhongqun
author_facet Li, Yalan
Sun, Zhen
Zhang, Lili
Yan, Jinchuan
Shao, Chen
Jing, Lele
Li, Lihua
Wang, Zhongqun
author_sort Li, Yalan
collection PubMed
description Vascular calcification is an abnormal cell-mediated process in which bone-specific hydroxyapatite crystals are actively deposited on the blood vessel wall and is a significant pathological basis for the increased incidence and mortality of adverse cardiovascular events. Macrophages play an important regulatory role in the occurrence, development, and regression of vascular calcification. After the tissue microenvironment changes, macrophages subsequently change their polarity and phenotype or secrete functional substances as an adaptive response. As research on macrophages continue to move into this field, we gain a new understanding of the mechanism of the formation and regression of vascular calcification, which might offer valuable new intervention targets for the prevention and inhibition of vascular calcification. This review summarizes a wealth of research in this field and explores the roles of macrophages in the development process of vascular calcification.
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spelling pubmed-72274442020-05-25 Role of Macrophages in the Progression and Regression of Vascular Calcification Li, Yalan Sun, Zhen Zhang, Lili Yan, Jinchuan Shao, Chen Jing, Lele Li, Lihua Wang, Zhongqun Front Pharmacol Pharmacology Vascular calcification is an abnormal cell-mediated process in which bone-specific hydroxyapatite crystals are actively deposited on the blood vessel wall and is a significant pathological basis for the increased incidence and mortality of adverse cardiovascular events. Macrophages play an important regulatory role in the occurrence, development, and regression of vascular calcification. After the tissue microenvironment changes, macrophages subsequently change their polarity and phenotype or secrete functional substances as an adaptive response. As research on macrophages continue to move into this field, we gain a new understanding of the mechanism of the formation and regression of vascular calcification, which might offer valuable new intervention targets for the prevention and inhibition of vascular calcification. This review summarizes a wealth of research in this field and explores the roles of macrophages in the development process of vascular calcification. Frontiers Media S.A. 2020-05-08 /pmc/articles/PMC7227444/ /pubmed/32457633 http://dx.doi.org/10.3389/fphar.2020.00661 Text en Copyright © 2020 Li, Sun, Zhang, Yan, Shao, Jing, Li and Wang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Yalan
Sun, Zhen
Zhang, Lili
Yan, Jinchuan
Shao, Chen
Jing, Lele
Li, Lihua
Wang, Zhongqun
Role of Macrophages in the Progression and Regression of Vascular Calcification
title Role of Macrophages in the Progression and Regression of Vascular Calcification
title_full Role of Macrophages in the Progression and Regression of Vascular Calcification
title_fullStr Role of Macrophages in the Progression and Regression of Vascular Calcification
title_full_unstemmed Role of Macrophages in the Progression and Regression of Vascular Calcification
title_short Role of Macrophages in the Progression and Regression of Vascular Calcification
title_sort role of macrophages in the progression and regression of vascular calcification
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227444/
https://www.ncbi.nlm.nih.gov/pubmed/32457633
http://dx.doi.org/10.3389/fphar.2020.00661
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