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Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation

Characteristics and risk factors (RFs) of community-acquired respiratory virus (CARV) infections after umbilical cord blood transplantation (UCBT) are lacking. We retrospectively analyzed CARV infections in 216 single-unit myeloablative UCBT recipients. One-hundred and fourteen episodes of CARV infe...

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Autores principales: Montoro, Juan, Sanz, Jaime, Lorenzo, Ignacio, Balaguer-Roselló, Aitana, Salavert, Miguel, Gómez, María Dolores, Guerreiro, Manuel, González Barberá, Eva M., Aguado, Cristina, Tofán, Luiza, Sanz, Guillermo F., Sanz, Miguel A., Piñana, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227453/
https://www.ncbi.nlm.nih.gov/pubmed/32415227
http://dx.doi.org/10.1038/s41409-020-0943-0
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author Montoro, Juan
Sanz, Jaime
Lorenzo, Ignacio
Balaguer-Roselló, Aitana
Salavert, Miguel
Gómez, María Dolores
Guerreiro, Manuel
González Barberá, Eva M.
Aguado, Cristina
Tofán, Luiza
Sanz, Guillermo F.
Sanz, Miguel A.
Piñana, José Luis
author_facet Montoro, Juan
Sanz, Jaime
Lorenzo, Ignacio
Balaguer-Roselló, Aitana
Salavert, Miguel
Gómez, María Dolores
Guerreiro, Manuel
González Barberá, Eva M.
Aguado, Cristina
Tofán, Luiza
Sanz, Guillermo F.
Sanz, Miguel A.
Piñana, José Luis
author_sort Montoro, Juan
collection PubMed
description Characteristics and risk factors (RFs) of community-acquired respiratory virus (CARV) infections after umbilical cord blood transplantation (UCBT) are lacking. We retrospectively analyzed CARV infections in 216 single-unit myeloablative UCBT recipients. One-hundred and fourteen episodes of CARV infections were diagnosed in 62 (29%) patients. Upper respiratory tract disease (URTD) occurred in 61 (54%) whereas lower respiratory tract disease (LRTD) in 53 (46%). The 5-year cumulative incidence of CARV infection was 29%. RFs for developing CARV infections were: prednisone-based graft-versus-host disease (GVHD) prophylaxis and grade II–IV acute GVHD. RFs analysis of CARV progression to LRTD identified 2007–2009 period and absolute lymphocyte count (ALC) < 0.5 × 10(9)/L. ALC < 0.5 × 10(9)/L had a negative impact on day 60 mortality in both overall CARV and those with LRTD, whereas proven LRTD was associated with higher day 60 mortality. CARV infections had a negative effect on non-relapse mortality. Overall survival at day 60 after CARV detection was significantly lower in recipients with LRTD compared with URTD (74% vs. 93%, respectively). In conclusion, CARV infections after UCBT are frequent and may have a negative effect in the outcomes, in particular in the context of lymphocytopenia.
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spelling pubmed-72274532020-05-18 Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation Montoro, Juan Sanz, Jaime Lorenzo, Ignacio Balaguer-Roselló, Aitana Salavert, Miguel Gómez, María Dolores Guerreiro, Manuel González Barberá, Eva M. Aguado, Cristina Tofán, Luiza Sanz, Guillermo F. Sanz, Miguel A. Piñana, José Luis Bone Marrow Transplant Article Characteristics and risk factors (RFs) of community-acquired respiratory virus (CARV) infections after umbilical cord blood transplantation (UCBT) are lacking. We retrospectively analyzed CARV infections in 216 single-unit myeloablative UCBT recipients. One-hundred and fourteen episodes of CARV infections were diagnosed in 62 (29%) patients. Upper respiratory tract disease (URTD) occurred in 61 (54%) whereas lower respiratory tract disease (LRTD) in 53 (46%). The 5-year cumulative incidence of CARV infection was 29%. RFs for developing CARV infections were: prednisone-based graft-versus-host disease (GVHD) prophylaxis and grade II–IV acute GVHD. RFs analysis of CARV progression to LRTD identified 2007–2009 period and absolute lymphocyte count (ALC) < 0.5 × 10(9)/L. ALC < 0.5 × 10(9)/L had a negative impact on day 60 mortality in both overall CARV and those with LRTD, whereas proven LRTD was associated with higher day 60 mortality. CARV infections had a negative effect on non-relapse mortality. Overall survival at day 60 after CARV detection was significantly lower in recipients with LRTD compared with URTD (74% vs. 93%, respectively). In conclusion, CARV infections after UCBT are frequent and may have a negative effect in the outcomes, in particular in the context of lymphocytopenia. Nature Publishing Group UK 2020-05-15 2020 /pmc/articles/PMC7227453/ /pubmed/32415227 http://dx.doi.org/10.1038/s41409-020-0943-0 Text en © The Author(s), under exclusive licence to Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Montoro, Juan
Sanz, Jaime
Lorenzo, Ignacio
Balaguer-Roselló, Aitana
Salavert, Miguel
Gómez, María Dolores
Guerreiro, Manuel
González Barberá, Eva M.
Aguado, Cristina
Tofán, Luiza
Sanz, Guillermo F.
Sanz, Miguel A.
Piñana, José Luis
Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation
title Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation
title_full Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation
title_fullStr Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation
title_full_unstemmed Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation
title_short Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation
title_sort community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227453/
https://www.ncbi.nlm.nih.gov/pubmed/32415227
http://dx.doi.org/10.1038/s41409-020-0943-0
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