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Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation
Characteristics and risk factors (RFs) of community-acquired respiratory virus (CARV) infections after umbilical cord blood transplantation (UCBT) are lacking. We retrospectively analyzed CARV infections in 216 single-unit myeloablative UCBT recipients. One-hundred and fourteen episodes of CARV infe...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227453/ https://www.ncbi.nlm.nih.gov/pubmed/32415227 http://dx.doi.org/10.1038/s41409-020-0943-0 |
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author | Montoro, Juan Sanz, Jaime Lorenzo, Ignacio Balaguer-Roselló, Aitana Salavert, Miguel Gómez, María Dolores Guerreiro, Manuel González Barberá, Eva M. Aguado, Cristina Tofán, Luiza Sanz, Guillermo F. Sanz, Miguel A. Piñana, José Luis |
author_facet | Montoro, Juan Sanz, Jaime Lorenzo, Ignacio Balaguer-Roselló, Aitana Salavert, Miguel Gómez, María Dolores Guerreiro, Manuel González Barberá, Eva M. Aguado, Cristina Tofán, Luiza Sanz, Guillermo F. Sanz, Miguel A. Piñana, José Luis |
author_sort | Montoro, Juan |
collection | PubMed |
description | Characteristics and risk factors (RFs) of community-acquired respiratory virus (CARV) infections after umbilical cord blood transplantation (UCBT) are lacking. We retrospectively analyzed CARV infections in 216 single-unit myeloablative UCBT recipients. One-hundred and fourteen episodes of CARV infections were diagnosed in 62 (29%) patients. Upper respiratory tract disease (URTD) occurred in 61 (54%) whereas lower respiratory tract disease (LRTD) in 53 (46%). The 5-year cumulative incidence of CARV infection was 29%. RFs for developing CARV infections were: prednisone-based graft-versus-host disease (GVHD) prophylaxis and grade II–IV acute GVHD. RFs analysis of CARV progression to LRTD identified 2007–2009 period and absolute lymphocyte count (ALC) < 0.5 × 10(9)/L. ALC < 0.5 × 10(9)/L had a negative impact on day 60 mortality in both overall CARV and those with LRTD, whereas proven LRTD was associated with higher day 60 mortality. CARV infections had a negative effect on non-relapse mortality. Overall survival at day 60 after CARV detection was significantly lower in recipients with LRTD compared with URTD (74% vs. 93%, respectively). In conclusion, CARV infections after UCBT are frequent and may have a negative effect in the outcomes, in particular in the context of lymphocytopenia. |
format | Online Article Text |
id | pubmed-7227453 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-72274532020-05-18 Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation Montoro, Juan Sanz, Jaime Lorenzo, Ignacio Balaguer-Roselló, Aitana Salavert, Miguel Gómez, María Dolores Guerreiro, Manuel González Barberá, Eva M. Aguado, Cristina Tofán, Luiza Sanz, Guillermo F. Sanz, Miguel A. Piñana, José Luis Bone Marrow Transplant Article Characteristics and risk factors (RFs) of community-acquired respiratory virus (CARV) infections after umbilical cord blood transplantation (UCBT) are lacking. We retrospectively analyzed CARV infections in 216 single-unit myeloablative UCBT recipients. One-hundred and fourteen episodes of CARV infections were diagnosed in 62 (29%) patients. Upper respiratory tract disease (URTD) occurred in 61 (54%) whereas lower respiratory tract disease (LRTD) in 53 (46%). The 5-year cumulative incidence of CARV infection was 29%. RFs for developing CARV infections were: prednisone-based graft-versus-host disease (GVHD) prophylaxis and grade II–IV acute GVHD. RFs analysis of CARV progression to LRTD identified 2007–2009 period and absolute lymphocyte count (ALC) < 0.5 × 10(9)/L. ALC < 0.5 × 10(9)/L had a negative impact on day 60 mortality in both overall CARV and those with LRTD, whereas proven LRTD was associated with higher day 60 mortality. CARV infections had a negative effect on non-relapse mortality. Overall survival at day 60 after CARV detection was significantly lower in recipients with LRTD compared with URTD (74% vs. 93%, respectively). In conclusion, CARV infections after UCBT are frequent and may have a negative effect in the outcomes, in particular in the context of lymphocytopenia. Nature Publishing Group UK 2020-05-15 2020 /pmc/articles/PMC7227453/ /pubmed/32415227 http://dx.doi.org/10.1038/s41409-020-0943-0 Text en © The Author(s), under exclusive licence to Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Article Montoro, Juan Sanz, Jaime Lorenzo, Ignacio Balaguer-Roselló, Aitana Salavert, Miguel Gómez, María Dolores Guerreiro, Manuel González Barberá, Eva M. Aguado, Cristina Tofán, Luiza Sanz, Guillermo F. Sanz, Miguel A. Piñana, José Luis Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation |
title | Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation |
title_full | Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation |
title_fullStr | Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation |
title_full_unstemmed | Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation |
title_short | Community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation |
title_sort | community acquired respiratory virus infections in adult patients undergoing umbilical cord blood transplantation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227453/ https://www.ncbi.nlm.nih.gov/pubmed/32415227 http://dx.doi.org/10.1038/s41409-020-0943-0 |
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