Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response...

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Detalles Bibliográficos
Autores principales: Blanco-Melo, Daniel, Nilsson-Payant, Benjamin E., Liu, Wen-Chun, Uhl, Skyler, Hoagland, Daisy, Møller, Rasmus, Jordan, Tristan X., Oishi, Kohei, Panis, Maryline, Sachs, David, Wang, Taia T., Schwartz, Robert E., Lim, Jean K., Albrecht, Randy A., tenOever, Benjamin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227586/
https://www.ncbi.nlm.nih.gov/pubmed/32416070
http://dx.doi.org/10.1016/j.cell.2020.04.026
Descripción
Sumario:Viral pandemics, such as the one caused by SARS-CoV-2, pose an imminent threat to humanity. Because of its recent emergence, there is a paucity of information regarding viral behavior and host response following SARS-CoV-2 infection. Here we offer an in-depth analysis of the transcriptional response to SARS-CoV-2 compared with other respiratory viruses. Cell and animal models of SARS-CoV-2 infection, in addition to transcriptional and serum profiling of COVID-19 patients, consistently revealed a unique and inappropriate inflammatory response. This response is defined by low levels of type I and III interferons juxtaposed to elevated chemokines and high expression of IL-6. We propose that reduced innate antiviral defenses coupled with exuberant inflammatory cytokine production are the defining and driving features of COVID-19.

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