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Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer

Activation of Crtc1 (also known as Mect1/Torc1) by a t(11;19) chromosomal rearrangement underlies the etiology of malignant salivary gland tumors. Since LKB1 is a target for mutational inactivation in lung cancer and was recently shown to regulate hepatic Crtc2/CREB transcriptional activity in mice,...

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Detalles Bibliográficos
Autores principales:	Komiya, Takefumi, Coxon, Amy, Park, Yoonsoo, Chen, Wei-dong, Zajac-Kaye, Maria, Meltzer, Paul, Karpova, Tatiana, Kaye, Frederic J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2009
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227613/ https://www.ncbi.nlm.nih.gov/pubmed/20010869 http://dx.doi.org/10.1038/onc.2009.453

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