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High chance to overcome the non-responder status to hepatitis B vaccine after a further full vaccination course: results from the extended study on healthcare students and workers in Florence, Italy

Healthcare workers (HCWs) are considered high-risk subjects for Hepatitis B Virus (HBV) infection due to occupational exposure to blood and body fluids. Vaccination represents the core strategy for HBV infection prevention. Following our previous publication on this topic, we aimed to assess the eff...

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Autores principales: Grazzini, Maddalena, Arcangeli, Giulio, Mucci, Nicola, Bonanni, Paolo, Bini, Costanza, Bechini, Angela, Boccalini, Sara, Tiscione, Emilia, Paolini, Diana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227660/
https://www.ncbi.nlm.nih.gov/pubmed/31634048
http://dx.doi.org/10.1080/21645515.2019.1680082
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author Grazzini, Maddalena
Arcangeli, Giulio
Mucci, Nicola
Bonanni, Paolo
Bini, Costanza
Bechini, Angela
Boccalini, Sara
Tiscione, Emilia
Paolini, Diana
author_facet Grazzini, Maddalena
Arcangeli, Giulio
Mucci, Nicola
Bonanni, Paolo
Bini, Costanza
Bechini, Angela
Boccalini, Sara
Tiscione, Emilia
Paolini, Diana
author_sort Grazzini, Maddalena
collection PubMed
description Healthcare workers (HCWs) are considered high-risk subjects for Hepatitis B Virus (HBV) infection due to occupational exposure to blood and body fluids. Vaccination represents the core strategy for HBV infection prevention. Following our previous publication on this topic, we aimed to assess the effectiveness of booster vaccine doses in eliciting the immunological response in seronegative (<10 mIU/mL) HCWs and students of Careggi Teaching Hospital, Florence (Italy). All subjects received primary vaccination course, and they were tested for serum anti-HBs antibodies. In seronegative subjects, a challenge dose of vaccine was administered and the test was repeated 1 month later. Six hundred and ninety-eight (87.8%) of 795 HCWs and students tested responded to the challenge dose. After this challenge dose, males more often had negative anti-HBs titer compared with females (15.9% vs 10.2%; p < .05). The completion of the second vaccination course was offered to subjects with persistently negative anti-HBs titer. 76.2% (32) of those who accepted the fifth dose, and 3 of the 5 who accepted the sixth dose seroconverted. This report shows the importance to convey a strong message to negative subjects at the initial anti-HBs dosage: accepting all the three additional vaccine doses allows the vast majority of them to obtain protection.
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spelling pubmed-72276602020-05-20 High chance to overcome the non-responder status to hepatitis B vaccine after a further full vaccination course: results from the extended study on healthcare students and workers in Florence, Italy Grazzini, Maddalena Arcangeli, Giulio Mucci, Nicola Bonanni, Paolo Bini, Costanza Bechini, Angela Boccalini, Sara Tiscione, Emilia Paolini, Diana Hum Vaccin Immunother Short Report Healthcare workers (HCWs) are considered high-risk subjects for Hepatitis B Virus (HBV) infection due to occupational exposure to blood and body fluids. Vaccination represents the core strategy for HBV infection prevention. Following our previous publication on this topic, we aimed to assess the effectiveness of booster vaccine doses in eliciting the immunological response in seronegative (<10 mIU/mL) HCWs and students of Careggi Teaching Hospital, Florence (Italy). All subjects received primary vaccination course, and they were tested for serum anti-HBs antibodies. In seronegative subjects, a challenge dose of vaccine was administered and the test was repeated 1 month later. Six hundred and ninety-eight (87.8%) of 795 HCWs and students tested responded to the challenge dose. After this challenge dose, males more often had negative anti-HBs titer compared with females (15.9% vs 10.2%; p < .05). The completion of the second vaccination course was offered to subjects with persistently negative anti-HBs titer. 76.2% (32) of those who accepted the fifth dose, and 3 of the 5 who accepted the sixth dose seroconverted. This report shows the importance to convey a strong message to negative subjects at the initial anti-HBs dosage: accepting all the three additional vaccine doses allows the vast majority of them to obtain protection. Taylor & Francis 2019-12-18 /pmc/articles/PMC7227660/ /pubmed/31634048 http://dx.doi.org/10.1080/21645515.2019.1680082 Text en © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Short Report
Grazzini, Maddalena
Arcangeli, Giulio
Mucci, Nicola
Bonanni, Paolo
Bini, Costanza
Bechini, Angela
Boccalini, Sara
Tiscione, Emilia
Paolini, Diana
High chance to overcome the non-responder status to hepatitis B vaccine after a further full vaccination course: results from the extended study on healthcare students and workers in Florence, Italy
title High chance to overcome the non-responder status to hepatitis B vaccine after a further full vaccination course: results from the extended study on healthcare students and workers in Florence, Italy
title_full High chance to overcome the non-responder status to hepatitis B vaccine after a further full vaccination course: results from the extended study on healthcare students and workers in Florence, Italy
title_fullStr High chance to overcome the non-responder status to hepatitis B vaccine after a further full vaccination course: results from the extended study on healthcare students and workers in Florence, Italy
title_full_unstemmed High chance to overcome the non-responder status to hepatitis B vaccine after a further full vaccination course: results from the extended study on healthcare students and workers in Florence, Italy
title_short High chance to overcome the non-responder status to hepatitis B vaccine after a further full vaccination course: results from the extended study on healthcare students and workers in Florence, Italy
title_sort high chance to overcome the non-responder status to hepatitis b vaccine after a further full vaccination course: results from the extended study on healthcare students and workers in florence, italy
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227660/
https://www.ncbi.nlm.nih.gov/pubmed/31634048
http://dx.doi.org/10.1080/21645515.2019.1680082
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