Identification and Analysis of Dysfunctional Genes and Pathways in CD8(+) T Cells of Non-Small Cell Lung Cancer Based on RNA Sequencing

Lung cancer, the most common of malignant tumors, is typically of the non-small cell (NSCLC) type. T-cell-based immunotherapies are a promising and powerful approach to treating NSCLCs. To characterize the CD8(+) T cells of non-small cell lung cancer, we re-analyzed the published RNA-Seq gene expres...

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Autores principales: Tao, Xuefang, Wu, Xiaotang, Huang, Tao, Mu, Deguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227791/
https://www.ncbi.nlm.nih.gov/pubmed/32457792
http://dx.doi.org/10.3389/fgene.2020.00352
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author Tao, Xuefang
Wu, Xiaotang
Huang, Tao
Mu, Deguang
author_facet Tao, Xuefang
Wu, Xiaotang
Huang, Tao
Mu, Deguang
author_sort Tao, Xuefang
collection PubMed
description Lung cancer, the most common of malignant tumors, is typically of the non-small cell (NSCLC) type. T-cell-based immunotherapies are a promising and powerful approach to treating NSCLCs. To characterize the CD8(+) T cells of non-small cell lung cancer, we re-analyzed the published RNA-Seq gene expression profiles of 36 CD8(+) T cell isolated from tumor (TIL) samples and 32 adjacent uninvolved lung (NTIL) samples. With an advanced Monte Carlo method of feature selection, we identified the CD8(+) TIL specific expression patterns. These patterns revealed the key dysfunctional genes and pathways in CD8(+) TIL and shed light on the molecular mechanisms of immunity and use of immunotherapy.
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spelling pubmed-72277912020-05-25 Identification and Analysis of Dysfunctional Genes and Pathways in CD8(+) T Cells of Non-Small Cell Lung Cancer Based on RNA Sequencing Tao, Xuefang Wu, Xiaotang Huang, Tao Mu, Deguang Front Genet Genetics Lung cancer, the most common of malignant tumors, is typically of the non-small cell (NSCLC) type. T-cell-based immunotherapies are a promising and powerful approach to treating NSCLCs. To characterize the CD8(+) T cells of non-small cell lung cancer, we re-analyzed the published RNA-Seq gene expression profiles of 36 CD8(+) T cell isolated from tumor (TIL) samples and 32 adjacent uninvolved lung (NTIL) samples. With an advanced Monte Carlo method of feature selection, we identified the CD8(+) TIL specific expression patterns. These patterns revealed the key dysfunctional genes and pathways in CD8(+) TIL and shed light on the molecular mechanisms of immunity and use of immunotherapy. Frontiers Media S.A. 2020-05-08 /pmc/articles/PMC7227791/ /pubmed/32457792 http://dx.doi.org/10.3389/fgene.2020.00352 Text en Copyright © 2020 Tao, Wu, Huang and Mu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Tao, Xuefang
Wu, Xiaotang
Huang, Tao
Mu, Deguang
Identification and Analysis of Dysfunctional Genes and Pathways in CD8(+) T Cells of Non-Small Cell Lung Cancer Based on RNA Sequencing
title Identification and Analysis of Dysfunctional Genes and Pathways in CD8(+) T Cells of Non-Small Cell Lung Cancer Based on RNA Sequencing
title_full Identification and Analysis of Dysfunctional Genes and Pathways in CD8(+) T Cells of Non-Small Cell Lung Cancer Based on RNA Sequencing
title_fullStr Identification and Analysis of Dysfunctional Genes and Pathways in CD8(+) T Cells of Non-Small Cell Lung Cancer Based on RNA Sequencing
title_full_unstemmed Identification and Analysis of Dysfunctional Genes and Pathways in CD8(+) T Cells of Non-Small Cell Lung Cancer Based on RNA Sequencing
title_short Identification and Analysis of Dysfunctional Genes and Pathways in CD8(+) T Cells of Non-Small Cell Lung Cancer Based on RNA Sequencing
title_sort identification and analysis of dysfunctional genes and pathways in cd8(+) t cells of non-small cell lung cancer based on rna sequencing
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227791/
https://www.ncbi.nlm.nih.gov/pubmed/32457792
http://dx.doi.org/10.3389/fgene.2020.00352
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