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Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease
PURPOSE: To evaluate circulating irisin levels in patients with active and controlled Cushing’s disease (CD). DESIGN: Forty-four patients with CD evaluated during the active phase and after 12 months of biochemical remission and 40 controls were recruited. METHODS: Phenotypic, anthropometric, hormon...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227819/ https://www.ncbi.nlm.nih.gov/pubmed/32494173 http://dx.doi.org/10.2147/DMSO.S249090 |
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author | Guarnotta, Valentina Prinzi, Antonio Pitrone, Maria Pizzolanti, Giuseppe Giordano, Carla |
author_facet | Guarnotta, Valentina Prinzi, Antonio Pitrone, Maria Pizzolanti, Giuseppe Giordano, Carla |
author_sort | Guarnotta, Valentina |
collection | PubMed |
description | PURPOSE: To evaluate circulating irisin levels in patients with active and controlled Cushing’s disease (CD). DESIGN: Forty-four patients with CD evaluated during the active phase and after 12 months of biochemical remission and 40 controls were recruited. METHODS: Phenotypic, anthropometric, hormonal and metabolic parameters, including insulin sensitivity estimation by homeostatic model of insulin resistance, Matsuda index and oral disposition index and circulating irisin levels were evaluated. RESULTS: Patients with active CD showed lower irisin levels compared to controls (p<0.001) and controlled CD (p<0.001). The independent variables significantly associated with irisin were waist circumference (WC) (p=0.025), body fat percentage (BF%) (p=0.009), PTH (p=0.007) and chair rising test (CRT) (p<0.001) in active CD and WC (p=0.013), BF% (p=0.014), PTH (p=0.038), CRT (p=0.029) and urinary-free cortisol (p<0.001) in controlled CD. CONCLUSION: Circulating irisin levels tend to be lower in patients with active CD compared to those with controlled CD and controls. They are strongly associated with osteosarcopenia and central obesity in CD and therefore may be a possible marker of diagnosis. |
format | Online Article Text |
id | pubmed-7227819 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-72278192020-06-02 Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease Guarnotta, Valentina Prinzi, Antonio Pitrone, Maria Pizzolanti, Giuseppe Giordano, Carla Diabetes Metab Syndr Obes Original Research PURPOSE: To evaluate circulating irisin levels in patients with active and controlled Cushing’s disease (CD). DESIGN: Forty-four patients with CD evaluated during the active phase and after 12 months of biochemical remission and 40 controls were recruited. METHODS: Phenotypic, anthropometric, hormonal and metabolic parameters, including insulin sensitivity estimation by homeostatic model of insulin resistance, Matsuda index and oral disposition index and circulating irisin levels were evaluated. RESULTS: Patients with active CD showed lower irisin levels compared to controls (p<0.001) and controlled CD (p<0.001). The independent variables significantly associated with irisin were waist circumference (WC) (p=0.025), body fat percentage (BF%) (p=0.009), PTH (p=0.007) and chair rising test (CRT) (p<0.001) in active CD and WC (p=0.013), BF% (p=0.014), PTH (p=0.038), CRT (p=0.029) and urinary-free cortisol (p<0.001) in controlled CD. CONCLUSION: Circulating irisin levels tend to be lower in patients with active CD compared to those with controlled CD and controls. They are strongly associated with osteosarcopenia and central obesity in CD and therefore may be a possible marker of diagnosis. Dove 2020-05-11 /pmc/articles/PMC7227819/ /pubmed/32494173 http://dx.doi.org/10.2147/DMSO.S249090 Text en © 2020 Guarnotta et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Guarnotta, Valentina Prinzi, Antonio Pitrone, Maria Pizzolanti, Giuseppe Giordano, Carla Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease |
title | Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease |
title_full | Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease |
title_fullStr | Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease |
title_full_unstemmed | Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease |
title_short | Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease |
title_sort | circulating irisin levels as a marker of osteosarcopenic-obesity in cushing’s disease |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227819/ https://www.ncbi.nlm.nih.gov/pubmed/32494173 http://dx.doi.org/10.2147/DMSO.S249090 |
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