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Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice
The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tissue regeneration. HIF-1 is negatively controlled by O(2)-dependent prolyl hydroxylases with a predominant role of prolyl hydroxylase 2 isoform (Phd2). Transgenic mice, hypomorphic for this isoform, accumulate more...
Autores principales: | Settelmeier, Stephan, Schreiber, Timm, Mäki, Joni, Byts, Nadiya, Koivunen, Peppi, Myllyharju, Johanna, Fandrey, Joachim, Winning, Sandra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228053/ https://www.ncbi.nlm.nih.gov/pubmed/32413092 http://dx.doi.org/10.1371/journal.pone.0233261 |
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