Cargando…

The influenza replication blocking inhibitor LASAG does not sensitize human epithelial cells for bacterial infections

Severe influenza virus (IV) infections still represent a major challenge to public health. To combat IV infections, vaccines and antiviral compounds are available. However, vaccine efficacies vary with very limited to no protection against newly emerging zoonotic IV introductions. In addition, the d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wilden, Janine J., van Krüchten, Andre, Gieselmann, Lutz, Hrincius, Eike R., Deinhardt-Emmer, Stefanie, Haupt, Karoline F., Preugschas, Hannah F., Niemann, Silke, Ludwig, Stephan, Ehrhardt, Christina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228112/ https://www.ncbi.nlm.nih.gov/pubmed/32413095 http://dx.doi.org/10.1371/journal.pone.0233052

Ejemplares similares

D,L-Lysine-Acetylsalicylate + Glycine (LASAG) Reduces SARS-CoV-2 Replication and Shows an Additive Effect with Remdesivir
por: Jungwirth, Johannes, et al.
Publicado: (2022)

Impact of Staphylococcus aureus Small Colony Variants on Human Lung Epithelial Cells with Subsequent Influenza Virus Infection
por: Wilden, Janine J., et al.
Publicado: (2020)

Inhibition of Phosphatidylinositol 3-Kinase by Pictilisib Blocks Influenza Virus Propagation in Cells and in Lungs of Infected Mice
por: Deinhardt-Emmer, Stefanie, et al.
Publicado: (2021)

Metabolic Modifications by Common Respiratory Viruses and Their Potential as New Antiviral Targets
por: Kleinehr, Jens, et al.
Publicado: (2021)

Targeting intracellular signaling as an antiviral strategy: aerosolized LASAG for the treatment of influenza in hospitalized patients
por: Scheuch, Gerhard, et al.
Publicado: (2018)

Staphylococcus aureus Pneumonia: Preceding Influenza Infection Paves the Way for Low-Virulent Strains
por: Deinhardt-Emmer, Stefanie, et al.
Publicado: (2019)

The Epidermal Growth Factor Receptor (EGFR) Promotes Uptake of Influenza A Viruses (IAV) into Host Cells
por: Eierhoff, Thorsten, et al.
Publicado: (2010)

Mitogen-activated protein kinases (MAPKs) regulate IL-6 over-production during concomitant influenza virus and Staphylococcus aureus infection
por: Klemm, Carolin, et al.
Publicado: (2017)

Capability of the viral NS1 proteins to bind to the cellular adaptor proteins Crk and CrkL determines sensitivity of influenza viruses to Crk/CrkL expression
por: Hrincius, ER, et al.
Publicado: (2009)

Influenza A viruses induce PI3-kinase activation by two interdependent mechanisms late in the infection cycle
por: Ehrhardt, C, et al.
Publicado: (2009)

The epidermal growth factor receptor (EGFR) contributes to efficient entry of influenza A viruses into host cells
por: Eierhoff, T, et al.
Publicado: (2009)

Neutralization of the Staphylococcus aureus Panton-Valentine leukocidin by African and Caucasian sera
por: Grebe, Tobias, et al.
Publicado: (2022)

Altered Signal Transduction in the Immune Response to Influenza Virus and S. pneumoniae or S. aureus Co-Infections
por: Wilden, Janine J., et al.
Publicado: (2021)

Early postmortem mapping of SARS-CoV-2 RNA in patients with COVID-19 and the correlation with tissue damage
por: Deinhardt-Emmer, Stefanie, et al.
Publicado: (2021)

Newborns’ passive humoral SARS-CoV-2 immunity following heterologous vaccination of the mother during pregnancy
por: Gloeckner, Stefan, et al.
Publicado: (2022)

Staphylococcus aureus Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages
por: Schicke, Elisabeth, et al.
Publicado: (2020)

The Inflammatory Profile of Obesity and the Role on Pulmonary Bacterial and Viral Infections
por: Hornung, Franziska, et al.
Publicado: (2021)

The Transmission of SARS-CoV-2 Infection on the Ocular Surface and Prevention Strategies
por: Kitazawa, Koji, et al.
Publicado: (2021)

A Plant Extract of Ribes nigrum folium Possesses Anti-Influenza Virus Activity In Vitro and In Vivo by Preventing Virus Entry to Host Cells
por: Ehrhardt, Christina, et al.
Publicado: (2013)

Thoracic adipose tissue contributes to severe virus infection of the lung
por: Hornung, Franziska, et al.
Publicado: (2023)

Robust Neutralizing Antibody Levels Detected after Either SARS-CoV-2 Vaccination or One Year after Infection
por: Glöckner, Stefan, et al.
Publicado: (2021)

Influenza Virus-Induced Paracrine Cellular Senescence of the Lung Contributes to Enhanced Viral Load
por: Schulz, Luise, et al.
Publicado: (2023)

First Time Isolation of Mycobacterium hassiacum From a Respiratory Sample
por: Deinhardt-Emmer, Stefanie, et al.
Publicado: (2018)

Viral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions
por: Liedmann, Swantje, et al.
Publicado: (2014)

Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice
por: Lambertz, Ruth L. O., et al.
Publicado: (2018)

The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses
por: Schreiber, André, et al.
Publicado: (2022)

Combined Action of Influenza Virus and Staphylococcus aureus Panton–Valentine Leukocidin Provokes Severe Lung Epithelium Damage
por: Niemann, Silke, et al.
Publicado: (2012)

Glycolytic interference blocks influenza A virus propagation by impairing viral polymerase-driven synthesis of genomic vRNA
por: Kleinehr, Jens, et al.
Publicado: (2023)

Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility
por: Brunnemann, Anne-Kathrin, et al.
Publicado: (2016)

SARS-CoV-2 Testing of Emergency Department Patients Using cobas(®) Liat(®) and eazyplex(®) Rapid Molecular Assays
por: Egerer, Renate, et al.
Publicado: (2023)

Clinical S. aureus Isolates Vary in Their Virulence to Promote Adaptation to the Host
por: Tuchscherr, Lorena, et al.
Publicado: (2019)

Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound
por: Bruchhagen, Christin, et al.
Publicado: (2018)

Raman spectroscopic cellomics for the detection of SARS‐CoV‐2‐associated neutrophil activation after TNF‐α stimulation
por: Pistiki, Aikaterini, et al.
Publicado: (2022)

Hypericum perforatum and Its Ingredients Hypericin and Pseudohypericin Demonstrate an Antiviral Activity against SARS-CoV-2
por: Mohamed, Fakry F., et al.
Publicado: (2022)

Ruling out COVID-19 by chest CT at emergency admission when prevalence is low: the prospective, observational SCOUT study
por: Teichgräber, Ulf, et al.
Publicado: (2021)

Single-Molecule Dynamics at a Bacterial Replication Fork after Nutritional Downshift or Chemically Induced Block in Replication
por: Hernández-Tamayo, Rogelio, et al.
Publicado: (2021)

Annexin A6-Balanced Late Endosomal Cholesterol Controls Influenza A Replication and Propagation
por: Musiol, Agnes, et al.
Publicado: (2013)

SARS-CoV-2 Causes Severe Epithelial Inflammation and Barrier Dysfunction
por: Deinhardt-Emmer, Stefanie, et al.
Publicado: (2021)

Stability of blocked replication forks in vivo
por: Mettrick, Karla A., et al.
Publicado: (2016)

Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis
por: Bierwagen, Jeff, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ge5oucdp6jbnk7cou7vmcpdbgh