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SULF1 suppresses Wnt3A-driven growth of bone metastatic prostate cancer in perlecan-modified 3D cancer-stroma-macrophage triculture models
Bone marrow stroma influences metastatic prostate cancer (PCa) progression, latency, and recurrence. At sites of PCa bone metastasis, cancer-associated fibroblasts and tumor-associated macrophages interact to establish a perlecan-rich desmoplastic stroma. As a heparan sulfate proteoglycan, perlecan...
Autores principales: | Brasil da Costa, Fabio Henrique, Lewis, Michael S., Truong, Anna, Carson, Daniel D., Farach-Carson, Mary C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228113/ https://www.ncbi.nlm.nih.gov/pubmed/32413029 http://dx.doi.org/10.1371/journal.pone.0230354 |
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