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The sensitivity of transcriptomics BMD modeling to the methods used for microarray data normalization
Whole-genome expression data generated by microarray studies have shown promise for quantitative human health risk assessment. While numerous approaches have been developed to determine benchmark doses (BMDs) from probeset-level dose responses, sensitivity of the results to methods used for normaliz...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228135/ https://www.ncbi.nlm.nih.gov/pubmed/32413060 http://dx.doi.org/10.1371/journal.pone.0232955 |