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Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile

PURPOSE: Environmental chemical exposures may adversely affect an array of adolescent health outcomes. Thus, we used the Health Outcomes and Measures of the Environment (HOME) study, a prospective cohort that recruited pregnant women and conducted longitudinal follow-up on children over the first 12...

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Autores principales: Braun, Joseph M, Buckley, Jessie P, Cecil, Kim M, Chen, Aimin, Kalkwarf, Heidi J, Lanphear, Bruce P, Xu, Yingying, Woeste, Anastasia, Yolton, Kimberly
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228515/
https://www.ncbi.nlm.nih.gov/pubmed/32385062
http://dx.doi.org/10.1136/bmjopen-2019-034838
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author Braun, Joseph M
Buckley, Jessie P
Cecil, Kim M
Chen, Aimin
Kalkwarf, Heidi J
Lanphear, Bruce P
Xu, Yingying
Woeste, Anastasia
Yolton, Kimberly
author_facet Braun, Joseph M
Buckley, Jessie P
Cecil, Kim M
Chen, Aimin
Kalkwarf, Heidi J
Lanphear, Bruce P
Xu, Yingying
Woeste, Anastasia
Yolton, Kimberly
author_sort Braun, Joseph M
collection PubMed
description PURPOSE: Environmental chemical exposures may adversely affect an array of adolescent health outcomes. Thus, we used the Health Outcomes and Measures of the Environment (HOME) study, a prospective cohort that recruited pregnant women and conducted longitudinal follow-up on children over the first 12 years of life, to determine if and when chemical exposures affect adolescent health. PARTICIPANTS: We recruited 468 pregnant women (age range: 18–45 years) from the Cincinnati, Ohio region to participate in a cohort study between March 2003 and January 2006. Follow-up included two clinic and one home visits during pregnancy, a delivery hospital visit, and four home and six clinic visits when children were aged 4 weeks and 1, 2, 3, 4, 5 and 8 years. Of 441 children available for follow-up, 396 (90%) completed at least one follow-up and 256 (58%) completed the most recent follow-up at 12 years of age (range: 11–14). FINDINGS TO DATE: Our new measures include maternal/child report of internalising symptoms, neuroimaging, dual-energy X-ray absorptiometry-derived estimates of lean/adipose tissue and bone mineral density, and cardiometabolic risk biomarkers. We assessed adolescent exposure to perfluoroalkyl substances, phenols, phthalates and flame retardants. Participants completing follow-up at 12 years of age were similar to the original cohort in terms of baseline factors. Most children had typical and expected values for this age on measures of internalising symptoms, body composition, bone density and cardiometabolic risk markers. Notably, 36% and 11% of children had scores indicative of potential anxiety and depressive disorders, respectively. Approximately 35% of children were overweight or obese, with higher prevalence among girls. Thirty-three per cent of children had borderline or high triglyceride concentrations (>90 mg/dL). FUTURE PLANS: We will examine associations of early life environmental chemical exposures with adolescent health measures while considering potential periods of heightened susceptibility and mixture effects. TRIAL REGISTRATION NUMBER: NCT00129324.
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spelling pubmed-72285152020-05-18 Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile Braun, Joseph M Buckley, Jessie P Cecil, Kim M Chen, Aimin Kalkwarf, Heidi J Lanphear, Bruce P Xu, Yingying Woeste, Anastasia Yolton, Kimberly BMJ Open Epidemiology PURPOSE: Environmental chemical exposures may adversely affect an array of adolescent health outcomes. Thus, we used the Health Outcomes and Measures of the Environment (HOME) study, a prospective cohort that recruited pregnant women and conducted longitudinal follow-up on children over the first 12 years of life, to determine if and when chemical exposures affect adolescent health. PARTICIPANTS: We recruited 468 pregnant women (age range: 18–45 years) from the Cincinnati, Ohio region to participate in a cohort study between March 2003 and January 2006. Follow-up included two clinic and one home visits during pregnancy, a delivery hospital visit, and four home and six clinic visits when children were aged 4 weeks and 1, 2, 3, 4, 5 and 8 years. Of 441 children available for follow-up, 396 (90%) completed at least one follow-up and 256 (58%) completed the most recent follow-up at 12 years of age (range: 11–14). FINDINGS TO DATE: Our new measures include maternal/child report of internalising symptoms, neuroimaging, dual-energy X-ray absorptiometry-derived estimates of lean/adipose tissue and bone mineral density, and cardiometabolic risk biomarkers. We assessed adolescent exposure to perfluoroalkyl substances, phenols, phthalates and flame retardants. Participants completing follow-up at 12 years of age were similar to the original cohort in terms of baseline factors. Most children had typical and expected values for this age on measures of internalising symptoms, body composition, bone density and cardiometabolic risk markers. Notably, 36% and 11% of children had scores indicative of potential anxiety and depressive disorders, respectively. Approximately 35% of children were overweight or obese, with higher prevalence among girls. Thirty-three per cent of children had borderline or high triglyceride concentrations (>90 mg/dL). FUTURE PLANS: We will examine associations of early life environmental chemical exposures with adolescent health measures while considering potential periods of heightened susceptibility and mixture effects. TRIAL REGISTRATION NUMBER: NCT00129324. BMJ Publishing Group 2020-05-07 /pmc/articles/PMC7228515/ /pubmed/32385062 http://dx.doi.org/10.1136/bmjopen-2019-034838 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Epidemiology
Braun, Joseph M
Buckley, Jessie P
Cecil, Kim M
Chen, Aimin
Kalkwarf, Heidi J
Lanphear, Bruce P
Xu, Yingying
Woeste, Anastasia
Yolton, Kimberly
Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile
title Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile
title_full Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile
title_fullStr Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile
title_full_unstemmed Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile
title_short Adolescent follow-up in the Health Outcomes and Measures of the Environment (HOME) Study: cohort profile
title_sort adolescent follow-up in the health outcomes and measures of the environment (home) study: cohort profile
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228515/
https://www.ncbi.nlm.nih.gov/pubmed/32385062
http://dx.doi.org/10.1136/bmjopen-2019-034838
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