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Heat shock and HSP70 regulate 5-FU-mediated caspase-1 activation in myeloid-derived suppressor cells and tumor growth in mice

BACKGROUND: We have previously shown that 5-fluorouracil (5-FU) selectively kills myeloid-derived suppressor cells (MDSCs) and activates NLRP3 (NOD-leucine rich repeat and pyrin containing protein 3) inflammasome. NLRP3 activation leads to caspase-1 activation and production of IL-1β, which in turn...

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Detalles Bibliográficos
Autores principales:	Pilot, Thomas, Fratti, Aurélie, Thinselin, Chloé, Perrichet, Anaïs, Demontoux, Lucie, Limagne, Emeric, Derangère, Valentin, Ilie, Alis, Ndiaye, Mané, Jacquin, Elise, Garrido, Carmen, Ghiringhelli, François, Chalmin, Fanny, Rébé, Cédric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Basic Tumor Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228666/ https://www.ncbi.nlm.nih.gov/pubmed/32385145 http://dx.doi.org/10.1136/jitc-2019-000478

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