ATAC-seq identifies thousands of extrachromosomal circular DNA in cancer and cell lines

Extrachromosomal circular DNAs (eccDNAs) are somatically mosaic and contribute to intercellular heterogeneity in normal and tumor cells. Because short eccDNAs are poorly chromatinized, we hypothesized that they are sequenced by tagmentation in ATAC-seq experiments without any enrichment of circular...

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Detalles Bibliográficos
Autores principales: Kumar, Pankaj, Kiran, Shashi, Saha, Shekhar, Su, Zhangli, Paulsen, Teressa, Chatrath, Ajay, Shibata, Yoshiyuki, Shibata, Etsuko, Dutta, Anindya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228742/
https://www.ncbi.nlm.nih.gov/pubmed/32440553
http://dx.doi.org/10.1126/sciadv.aba2489

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