Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization

The transcription factor interferon regulatory factor 5 (IRF5) plays essential roles in pathogen-induced immunity downstream of Toll-, nucleotide-binding oligomerization domain–, and retinoic acid–inducible gene I–like receptors and is an autoimmune susceptibility gene. Normally, inactive in the cyt...

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Detalles Bibliográficos
Autores principales: Banga, Jaspreet, Srinivasan, Dinesh, Sun, Chia-Chi, Thompson, Cherrie D., Milletti, Francesca, Huang, Kuo-Sen, Hamilton, Shannon, Song, Su, Hoffman, Ann F., Qin, Yajuan Gu, Matta, Bharati, LaPan, Margaret, Guo, Qin, Lu, Gang, Li, Dan, Qian, Hong, Bolin, David R., Liang, Lena, Wartchow, Charles, Qiu, Jin, Downing, Michelle, Narula, Satwant, Fotouhi, Nader, DeMartino, Julie A., Tan, Seng-Lai, Chen, Gang, Barnes, Betsy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228753/
https://www.ncbi.nlm.nih.gov/pubmed/32440537
http://dx.doi.org/10.1126/sciadv.aay1057

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