Cardiovascular Safety of Potential Drugs for the Treatment of Coronavirus Disease 2019

Coronavirus disease 2019 (COVID-19) has become a global pandemic. It is still uncontrolled in most countries and no therapies are currently available. Various drugs are under investigation for its treatment. The disease is known to have worse outcomes in patients who have underlying cardiovascular d...

Descripción completa

Detalles Bibliográficos
Autores principales: Aggarwal, Gaurav, Henry, Brandon Michael, Aggarwal, Saurabh, Bangalore, Sripal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228893/
https://www.ncbi.nlm.nih.gov/pubmed/32425199
http://dx.doi.org/10.1016/j.amjcard.2020.04.054
_version_ 1783534652974170112
author Aggarwal, Gaurav
Henry, Brandon Michael
Aggarwal, Saurabh
Bangalore, Sripal
author_facet Aggarwal, Gaurav
Henry, Brandon Michael
Aggarwal, Saurabh
Bangalore, Sripal
author_sort Aggarwal, Gaurav
collection PubMed
description Coronavirus disease 2019 (COVID-19) has become a global pandemic. It is still uncontrolled in most countries and no therapies are currently available. Various drugs are under investigation for its treatment. The disease is known to have worse outcomes in patients who have underlying cardiovascular disease. Chloroquine/hydroxychloroquine, azithromycin, remdesivir and lopinavir/ritonavir are currently being studied in trials and show some promise. Conduction disorders, heart failure, and mortality have been reported with the use of these drugs. It is important to have knowledge of potential cardiotoxic effects of these drugs before using them for COVID-19 patients for better allocation of healthcare resources and improvement in clinical outcomes.
format Online
Article
Text
id pubmed-7228893
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-72288932020-05-18 Cardiovascular Safety of Potential Drugs for the Treatment of Coronavirus Disease 2019 Aggarwal, Gaurav Henry, Brandon Michael Aggarwal, Saurabh Bangalore, Sripal Am J Cardiol Article Coronavirus disease 2019 (COVID-19) has become a global pandemic. It is still uncontrolled in most countries and no therapies are currently available. Various drugs are under investigation for its treatment. The disease is known to have worse outcomes in patients who have underlying cardiovascular disease. Chloroquine/hydroxychloroquine, azithromycin, remdesivir and lopinavir/ritonavir are currently being studied in trials and show some promise. Conduction disorders, heart failure, and mortality have been reported with the use of these drugs. It is important to have knowledge of potential cardiotoxic effects of these drugs before using them for COVID-19 patients for better allocation of healthcare resources and improvement in clinical outcomes. Elsevier Inc. 2020-08-01 2020-05-16 /pmc/articles/PMC7228893/ /pubmed/32425199 http://dx.doi.org/10.1016/j.amjcard.2020.04.054 Text en © 2020 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Aggarwal, Gaurav
Henry, Brandon Michael
Aggarwal, Saurabh
Bangalore, Sripal
Cardiovascular Safety of Potential Drugs for the Treatment of Coronavirus Disease 2019
title Cardiovascular Safety of Potential Drugs for the Treatment of Coronavirus Disease 2019
title_full Cardiovascular Safety of Potential Drugs for the Treatment of Coronavirus Disease 2019
title_fullStr Cardiovascular Safety of Potential Drugs for the Treatment of Coronavirus Disease 2019
title_full_unstemmed Cardiovascular Safety of Potential Drugs for the Treatment of Coronavirus Disease 2019
title_short Cardiovascular Safety of Potential Drugs for the Treatment of Coronavirus Disease 2019
title_sort cardiovascular safety of potential drugs for the treatment of coronavirus disease 2019
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228893/
https://www.ncbi.nlm.nih.gov/pubmed/32425199
http://dx.doi.org/10.1016/j.amjcard.2020.04.054
work_keys_str_mv AT aggarwalgaurav cardiovascularsafetyofpotentialdrugsforthetreatmentofcoronavirusdisease2019
AT henrybrandonmichael cardiovascularsafetyofpotentialdrugsforthetreatmentofcoronavirusdisease2019
AT aggarwalsaurabh cardiovascularsafetyofpotentialdrugsforthetreatmentofcoronavirusdisease2019
AT bangaloresripal cardiovascularsafetyofpotentialdrugsforthetreatmentofcoronavirusdisease2019

Ejemplares similares