Studies of insulin and proinsulin in pancreas and serum support the existence of aetiopathological endotypes of type 1 diabetes associated with age at diagnosis

AIMS/HYPOTHESIS: It is unclear whether type 1 diabetes is a single disease or if endotypes exist. Our aim was to use a unique collection of pancreas samples recovered soon after disease onset to resolve this issue. METHODS: Immunohistological analysis was used to determine the distribution of proins...

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Detalles Bibliográficos
Autores principales: Leete, Pia, Oram, Richard A., McDonald, Timothy J., Shields, Beverley M., Ziller, Clemens, Hattersley, Andrew T., Richardson, Sarah J., Morgan, Noel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228905/
https://www.ncbi.nlm.nih.gov/pubmed/32172310
http://dx.doi.org/10.1007/s00125-020-05115-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228905/
https://www.ncbi.nlm.nih.gov/pubmed/32172310
http://dx.doi.org/10.1007/s00125-020-05115-6

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