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Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden

Cancers harbor many somatic mutations and germline variants, we hypothesized that the combined effect of germline variants that alter the structure, expression, or function of protein-coding regions of cancer-biology related genes (gHFI) determines which and how many somatic mutations (sM) must occu...

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Detalles Bibliográficos
Autores principales:	Qing, Tao, Mohsen, Hussein, Marczyk, Michal, Ye, Yixuan, O’Meara, Tess, Zhao, Hongyu, Townsend, Jeffrey P., Gerstein, Mark, Hatzis, Christos, Kluger, Yuval, Pusztai, Lajos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228928/ https://www.ncbi.nlm.nih.gov/pubmed/32415133 http://dx.doi.org/10.1038/s41467-020-16293-7

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