Cargando…

Reorganization of theta phase-locking in the orbitofrontal cortex drives cocaine choice under the influence

Cortical theta oscillations of neuronal activity are a fundamental mechanism driving goal-directed behavior. We previously identified in the rat orbitofrontal cortex (OFC) a neuronal correlate of individual preferences between cocaine use and an alternative nondrug reward (i.e. saccharin). Whether t...

Descripción completa

Detalles Bibliográficos
Autores principales: Guillem, Karine, Ahmed, Serge H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228935/
https://www.ncbi.nlm.nih.gov/pubmed/32415278
http://dx.doi.org/10.1038/s41598-020-64962-w
_version_ 1783534662807715840
author Guillem, Karine
Ahmed, Serge H.
author_facet Guillem, Karine
Ahmed, Serge H.
author_sort Guillem, Karine
collection PubMed
description Cortical theta oscillations of neuronal activity are a fundamental mechanism driving goal-directed behavior. We previously identified in the rat orbitofrontal cortex (OFC) a neuronal correlate of individual preferences between cocaine use and an alternative nondrug reward (i.e. saccharin). Whether theta oscillations are also associated with choice behavior between a drug and a nondrug reward remains unknown. Here we investigated the temporal structure between single unit activity and theta band oscillations (4–12 Hz) in the OFC of rats choosing between cocaine and saccharin. First, we found that the relative amplitude of theta oscillations is associated with subjective value and preference between two rewards. Second, OFC phase-locked neurons fired on opposite phase of the theta oscillation during saccharin and cocaine rewards, suggesting the existence of two separable neuronal assemblies. Finally, the pharmacological influence of cocaine at the moment of choice altered both theta band power and theta phase-locking in the OFC. That is, this drug influence shifted spike-phase relative to theta cycle and decreased the synchronization of OFC neurons relative to the theta oscillation. Overall, this study indicates that the reorganization of theta phase-locking under the influence of cocaine biases OFC neuronal assemblies in favor of cocaine choice and at the expense of a normally preferred alternative, a neuronal change that may contribute to drug preference in cocaine addiction.
format Online
Article
Text
id pubmed-7228935
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-72289352020-05-20 Reorganization of theta phase-locking in the orbitofrontal cortex drives cocaine choice under the influence Guillem, Karine Ahmed, Serge H. Sci Rep Article Cortical theta oscillations of neuronal activity are a fundamental mechanism driving goal-directed behavior. We previously identified in the rat orbitofrontal cortex (OFC) a neuronal correlate of individual preferences between cocaine use and an alternative nondrug reward (i.e. saccharin). Whether theta oscillations are also associated with choice behavior between a drug and a nondrug reward remains unknown. Here we investigated the temporal structure between single unit activity and theta band oscillations (4–12 Hz) in the OFC of rats choosing between cocaine and saccharin. First, we found that the relative amplitude of theta oscillations is associated with subjective value and preference between two rewards. Second, OFC phase-locked neurons fired on opposite phase of the theta oscillation during saccharin and cocaine rewards, suggesting the existence of two separable neuronal assemblies. Finally, the pharmacological influence of cocaine at the moment of choice altered both theta band power and theta phase-locking in the OFC. That is, this drug influence shifted spike-phase relative to theta cycle and decreased the synchronization of OFC neurons relative to the theta oscillation. Overall, this study indicates that the reorganization of theta phase-locking under the influence of cocaine biases OFC neuronal assemblies in favor of cocaine choice and at the expense of a normally preferred alternative, a neuronal change that may contribute to drug preference in cocaine addiction. Nature Publishing Group UK 2020-05-15 /pmc/articles/PMC7228935/ /pubmed/32415278 http://dx.doi.org/10.1038/s41598-020-64962-w Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Guillem, Karine
Ahmed, Serge H.
Reorganization of theta phase-locking in the orbitofrontal cortex drives cocaine choice under the influence
title Reorganization of theta phase-locking in the orbitofrontal cortex drives cocaine choice under the influence
title_full Reorganization of theta phase-locking in the orbitofrontal cortex drives cocaine choice under the influence
title_fullStr Reorganization of theta phase-locking in the orbitofrontal cortex drives cocaine choice under the influence
title_full_unstemmed Reorganization of theta phase-locking in the orbitofrontal cortex drives cocaine choice under the influence
title_short Reorganization of theta phase-locking in the orbitofrontal cortex drives cocaine choice under the influence
title_sort reorganization of theta phase-locking in the orbitofrontal cortex drives cocaine choice under the influence
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228935/
https://www.ncbi.nlm.nih.gov/pubmed/32415278
http://dx.doi.org/10.1038/s41598-020-64962-w
work_keys_str_mv AT guillemkarine reorganizationofthetaphaselockingintheorbitofrontalcortexdrivescocainechoiceundertheinfluence
AT ahmedsergeh reorganizationofthetaphaselockingintheorbitofrontalcortexdrivescocainechoiceundertheinfluence