Oncogenic hijacking of a developmental transcription factor evokes vulnerability toward oxidative stress in Ewing sarcoma

Ewing sarcoma (EwS) is an aggressive childhood cancer likely originating from mesenchymal stem cells or osteo-chondrogenic progenitors. It is characterized by fusion oncoproteins involving EWSR1 and variable members of the ETS-family of transcription factors (in 85% FLI1). EWSR1-FLI1 can induce targ...

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Detalles Bibliográficos
Autores principales: Marchetto, Aruna, Ohmura, Shunya, Orth, Martin F., Knott, Maximilian M. L., Colombo, Maria V., Arrigoni, Chiara, Bardinet, Victor, Saucier, David, Wehweck, Fabienne S., Li, Jing, Stein, Stefanie, Gerke, Julia S., Baldauf, Michaela C., Musa, Julian, Dallmayer, Marlene, Romero-Pérez, Laura, Hölting, Tilman L. B., Amatruda, James F., Cossarizza, Andrea, Henssen, Anton G., Kirchner, Thomas, Moretti, Matteo, Cidre-Aranaz, Florencia, Sannino, Giuseppina, Grünewald, Thomas G. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228971/
https://www.ncbi.nlm.nih.gov/pubmed/32415069
http://dx.doi.org/10.1038/s41467-020-16244-2

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