One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension

AIMS/HYPOTHESIS: Physical inactivity, low mitochondrial function, increased intramyocellular lipid (IMCL) deposition and reduced insulin sensitivity are common denominators of chronic metabolic disorders, like obesity and type 2 diabetes. Yet, whether low mitochondrial function predisposes to insuli...

Descripción completa

Detalles Bibliográficos
Autores principales: Bilet, Lena, Phielix, Esther, van de Weijer, Tineke, Gemmink, Anne, Bosma, Madeleen, Moonen-Kornips, Esther, Jorgensen, Johanna A., Schaart, Gert, Zhang, Dongyan, Meijer, Kenneth, Hopman, Maria, Hesselink, Matthijs K. C., Ouwens, D. Margriet, Shulman, Gerald I., Schrauwen-Hinderling, Vera B., Schrauwen, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228997/
https://www.ncbi.nlm.nih.gov/pubmed/32185462
http://dx.doi.org/10.1007/s00125-020-05128-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228997/
https://www.ncbi.nlm.nih.gov/pubmed/32185462
http://dx.doi.org/10.1007/s00125-020-05128-1

Ejemplares similares