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Comparative Responses in Lung Function Measurements with Tiotropium in Adolescents and Adults, and Across Asthma Severities: A Post Hoc Analysis

INTRODUCTION: Airway obstruction is usually assessed by measuring forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and peak expiratory flow (PEF). This post hoc study investigated comparative responses of lung function measurements in adults and adolescents (full analysis set, N...

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Autores principales: Halpin, David M. G., Hamelmann, Eckard H., Frith, Peter A., Moroni-Zentgraf, Petra M., van Hecke, Benjamin, Unseld, Anna, Kerstjens, Huib A. M., Szefler, Stanley J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229088/
https://www.ncbi.nlm.nih.gov/pubmed/32180164
http://dx.doi.org/10.1007/s41030-020-00113-w
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author Halpin, David M. G.
Hamelmann, Eckard H.
Frith, Peter A.
Moroni-Zentgraf, Petra M.
van Hecke, Benjamin
Unseld, Anna
Kerstjens, Huib A. M.
Szefler, Stanley J.
author_facet Halpin, David M. G.
Hamelmann, Eckard H.
Frith, Peter A.
Moroni-Zentgraf, Petra M.
van Hecke, Benjamin
Unseld, Anna
Kerstjens, Huib A. M.
Szefler, Stanley J.
author_sort Halpin, David M. G.
collection PubMed
description INTRODUCTION: Airway obstruction is usually assessed by measuring forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and peak expiratory flow (PEF). This post hoc study investigated comparative responses of lung function measurements in adults and adolescents (full analysis set, N = 3873) following treatment with tiotropium Respimat(®). METHODS: Lung function outcomes were analysed from five phase III trials in adults (≥ 18 years) with symptomatic severe, moderate and mild asthma (PrimoTinA-asthma(®), MezzoTinA-asthma(®) and GraziaTinA-asthma(®), respectively), and one phase III trial in adolescents (12–17 years) with symptomatic moderate asthma (RubaTinA-asthma(®)). Changes from baseline versus placebo in FEV(1), FVC, PEF and FEV(1)/FVC ratio with tiotropium 5 µg or 2.5 µg added to at least stable inhaled corticosteroids at week 24 (week 12 in GraziaTinA-asthma) were analysed. RESULTS: All lung function measures improved in all studies with tiotropium 5 µg (mean change from baseline versus placebo), including peak FEV(1) (110–185 mL), peak FVC (57–95 mL) and morning PEF (15.8–25.6 L/min). Changes in adolescents were smaller than those in adults, and were statistically significant primarily for FEV(1) and PEF, but not for FVC. CONCLUSION: Consistent improvements were seen across all lung function measures with the addition of tiotropium to other asthma treatments in adults across all severities, whereas the improvements with tiotropium in adolescents primarily impacted measures of flow rather than lung volume. This may reflect less pronounced airway remodelling and air trapping in adolescents with asthma versus adults.
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spelling pubmed-72290882020-05-18 Comparative Responses in Lung Function Measurements with Tiotropium in Adolescents and Adults, and Across Asthma Severities: A Post Hoc Analysis Halpin, David M. G. Hamelmann, Eckard H. Frith, Peter A. Moroni-Zentgraf, Petra M. van Hecke, Benjamin Unseld, Anna Kerstjens, Huib A. M. Szefler, Stanley J. Pulm Ther Brief Report INTRODUCTION: Airway obstruction is usually assessed by measuring forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and peak expiratory flow (PEF). This post hoc study investigated comparative responses of lung function measurements in adults and adolescents (full analysis set, N = 3873) following treatment with tiotropium Respimat(®). METHODS: Lung function outcomes were analysed from five phase III trials in adults (≥ 18 years) with symptomatic severe, moderate and mild asthma (PrimoTinA-asthma(®), MezzoTinA-asthma(®) and GraziaTinA-asthma(®), respectively), and one phase III trial in adolescents (12–17 years) with symptomatic moderate asthma (RubaTinA-asthma(®)). Changes from baseline versus placebo in FEV(1), FVC, PEF and FEV(1)/FVC ratio with tiotropium 5 µg or 2.5 µg added to at least stable inhaled corticosteroids at week 24 (week 12 in GraziaTinA-asthma) were analysed. RESULTS: All lung function measures improved in all studies with tiotropium 5 µg (mean change from baseline versus placebo), including peak FEV(1) (110–185 mL), peak FVC (57–95 mL) and morning PEF (15.8–25.6 L/min). Changes in adolescents were smaller than those in adults, and were statistically significant primarily for FEV(1) and PEF, but not for FVC. CONCLUSION: Consistent improvements were seen across all lung function measures with the addition of tiotropium to other asthma treatments in adults across all severities, whereas the improvements with tiotropium in adolescents primarily impacted measures of flow rather than lung volume. This may reflect less pronounced airway remodelling and air trapping in adolescents with asthma versus adults. Springer Healthcare 2020-03-16 /pmc/articles/PMC7229088/ /pubmed/32180164 http://dx.doi.org/10.1007/s41030-020-00113-w Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Brief Report
Halpin, David M. G.
Hamelmann, Eckard H.
Frith, Peter A.
Moroni-Zentgraf, Petra M.
van Hecke, Benjamin
Unseld, Anna
Kerstjens, Huib A. M.
Szefler, Stanley J.
Comparative Responses in Lung Function Measurements with Tiotropium in Adolescents and Adults, and Across Asthma Severities: A Post Hoc Analysis
title Comparative Responses in Lung Function Measurements with Tiotropium in Adolescents and Adults, and Across Asthma Severities: A Post Hoc Analysis
title_full Comparative Responses in Lung Function Measurements with Tiotropium in Adolescents and Adults, and Across Asthma Severities: A Post Hoc Analysis
title_fullStr Comparative Responses in Lung Function Measurements with Tiotropium in Adolescents and Adults, and Across Asthma Severities: A Post Hoc Analysis
title_full_unstemmed Comparative Responses in Lung Function Measurements with Tiotropium in Adolescents and Adults, and Across Asthma Severities: A Post Hoc Analysis
title_short Comparative Responses in Lung Function Measurements with Tiotropium in Adolescents and Adults, and Across Asthma Severities: A Post Hoc Analysis
title_sort comparative responses in lung function measurements with tiotropium in adolescents and adults, and across asthma severities: a post hoc analysis
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229088/
https://www.ncbi.nlm.nih.gov/pubmed/32180164
http://dx.doi.org/10.1007/s41030-020-00113-w
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