Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine

The 2019–2020 Northern Hemisphere influenza vaccine includes antigens from 3c3.A H3N2 viruses; however, over half of circulating H3N2 viruses belong to subclade 3c2.A1b. Here, we analyze antibody responses elicited by the egg-adapted 3c3.A H3N2 vaccine strain in ferrets and humans. We find that this...

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Autores principales: Gouma, Sigrid, Weirick, Madison, Hensley, Scott E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229105/
https://www.ncbi.nlm.nih.gov/pubmed/32415074
http://dx.doi.org/10.1038/s41467-020-16183-y
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author Gouma, Sigrid
Weirick, Madison
Hensley, Scott E.
author_facet Gouma, Sigrid
Weirick, Madison
Hensley, Scott E.
author_sort Gouma, Sigrid
collection PubMed
description The 2019–2020 Northern Hemisphere influenza vaccine includes antigens from 3c3.A H3N2 viruses; however, over half of circulating H3N2 viruses belong to subclade 3c2.A1b. Here, we analyze antibody responses elicited by the egg-adapted 3c3.A H3N2 vaccine strain in ferrets and humans. We find that this vaccine strain elicits antibodies that have reduced reactivity to a wild-type 3c3.A strain and very limited reactivity to 3c2.A strains, including the currently circulating 3c2.A1b strain.
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spelling pubmed-72291052020-06-05 Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine Gouma, Sigrid Weirick, Madison Hensley, Scott E. Nat Commun Article The 2019–2020 Northern Hemisphere influenza vaccine includes antigens from 3c3.A H3N2 viruses; however, over half of circulating H3N2 viruses belong to subclade 3c2.A1b. Here, we analyze antibody responses elicited by the egg-adapted 3c3.A H3N2 vaccine strain in ferrets and humans. We find that this vaccine strain elicits antibodies that have reduced reactivity to a wild-type 3c3.A strain and very limited reactivity to 3c2.A strains, including the currently circulating 3c2.A1b strain. Nature Publishing Group UK 2020-05-15 /pmc/articles/PMC7229105/ /pubmed/32415074 http://dx.doi.org/10.1038/s41467-020-16183-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Gouma, Sigrid
Weirick, Madison
Hensley, Scott E.
Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine
title Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine
title_full Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine
title_fullStr Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine
title_full_unstemmed Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine
title_short Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine
title_sort antigenic assessment of the h3n2 component of the 2019-2020 northern hemisphere influenza vaccine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229105/
https://www.ncbi.nlm.nih.gov/pubmed/32415074
http://dx.doi.org/10.1038/s41467-020-16183-y
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