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Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation

Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed of the five LRRC8A-E isoforms, are pore-forming components of the volume-regulated anion channel (VRAC). LRRC8A and at least one of the other LRRC8 isoforms assemble into heteromers to generate VRAC transport activities...

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Detalles Bibliográficos
Autores principales:	Nakamura, Ryoki, Numata, Tomohiro, Kasuya, Go, Yokoyama, Takeshi, Nishizawa, Tomohiro, Kusakizako, Tsukasa, Kato, Takafumi, Hagino, Tatsuya, Dohmae, Naoshi, Inoue, Masato, Watanabe, Kengo, Ichijo, Hidenori, Kikkawa, Masahide, Shirouzu, Mikako, Jentsch, Thomas J., Ishitani, Ryuichiro, Okada, Yasunobu, Nureki, Osamu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229184/ https://www.ncbi.nlm.nih.gov/pubmed/32415200 http://dx.doi.org/10.1038/s42003-020-0951-z

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