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The frequency of pulmonary hypertension in newborn with intrauterine growth restriction
Intrauterine growth restriction (IUGR) is a clinical definition applied to neonates born with clinical features of malnutrition and in-utero growth retardation irrespective of their birth weight percentile. This study was aimed to determine the frequency of pulmonary hypertension (PH) in neonates wi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229189/ https://www.ncbi.nlm.nih.gov/pubmed/32415157 http://dx.doi.org/10.1038/s41598-020-65065-2 |
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author | Abbas, Ghulam Shah, Shahid Hanif, Muhammad Shah, Abid Rehman, Anees ur Tahir, Sana Nayab, Komal Asghar, Arzoo |
author_facet | Abbas, Ghulam Shah, Shahid Hanif, Muhammad Shah, Abid Rehman, Anees ur Tahir, Sana Nayab, Komal Asghar, Arzoo |
author_sort | Abbas, Ghulam |
collection | PubMed |
description | Intrauterine growth restriction (IUGR) is a clinical definition applied to neonates born with clinical features of malnutrition and in-utero growth retardation irrespective of their birth weight percentile. This study was aimed to determine the frequency of pulmonary hypertension (PH) in neonates with IUGR. In this descriptive cross-sectional study, we followed 96 neonates with IUGR (≤28 days) and 38 neonates without IUGR born in the department of the neonatal intensive care unit children hospital complex Multan, Pakistan. We analyzed certain factors such as gender, gestational age (GA) (weeks), birth weight (BW in kg), weight percentile (WP) for GA, meconium aspiration syndrome (MAS), birth asphyxia (BA) and respiratory distress syndrome (RDS) for pulmonary hypertension (PH) in IUGR and non-IUGR group. GA was measured by the Ballard scoring system. Echocardiography was performed for all patients by the pediatric cardiologist to measure pulmonary arterial (PA) pressure using Bernoulli’s equation. Out of total 96 IUGR neonates, 33.3% (n = 32) suffered from PH, of which 65.3% (n = 18) were male and 43.7% (n = 14) were female. The percentages of IUGR neonates with BA, MAS and RDS were 34.4%, 18.8% and 22.9% respectively. The data were analyzed using the SPSS-16 software to test the statistical significance of the results. A p-value less than 0.05 was considered significant. When the chi-square test was applied, it depicted that MAS was significantly associated with PH in IUGR neonates (p = 0.0001) compared to non-IUGR neonates. Our findings suggested an increased chance of PH in IUGR neonates and MAS may be a strong factor. |
format | Online Article Text |
id | pubmed-7229189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-72291892020-05-26 The frequency of pulmonary hypertension in newborn with intrauterine growth restriction Abbas, Ghulam Shah, Shahid Hanif, Muhammad Shah, Abid Rehman, Anees ur Tahir, Sana Nayab, Komal Asghar, Arzoo Sci Rep Article Intrauterine growth restriction (IUGR) is a clinical definition applied to neonates born with clinical features of malnutrition and in-utero growth retardation irrespective of their birth weight percentile. This study was aimed to determine the frequency of pulmonary hypertension (PH) in neonates with IUGR. In this descriptive cross-sectional study, we followed 96 neonates with IUGR (≤28 days) and 38 neonates without IUGR born in the department of the neonatal intensive care unit children hospital complex Multan, Pakistan. We analyzed certain factors such as gender, gestational age (GA) (weeks), birth weight (BW in kg), weight percentile (WP) for GA, meconium aspiration syndrome (MAS), birth asphyxia (BA) and respiratory distress syndrome (RDS) for pulmonary hypertension (PH) in IUGR and non-IUGR group. GA was measured by the Ballard scoring system. Echocardiography was performed for all patients by the pediatric cardiologist to measure pulmonary arterial (PA) pressure using Bernoulli’s equation. Out of total 96 IUGR neonates, 33.3% (n = 32) suffered from PH, of which 65.3% (n = 18) were male and 43.7% (n = 14) were female. The percentages of IUGR neonates with BA, MAS and RDS were 34.4%, 18.8% and 22.9% respectively. The data were analyzed using the SPSS-16 software to test the statistical significance of the results. A p-value less than 0.05 was considered significant. When the chi-square test was applied, it depicted that MAS was significantly associated with PH in IUGR neonates (p = 0.0001) compared to non-IUGR neonates. Our findings suggested an increased chance of PH in IUGR neonates and MAS may be a strong factor. Nature Publishing Group UK 2020-05-15 /pmc/articles/PMC7229189/ /pubmed/32415157 http://dx.doi.org/10.1038/s41598-020-65065-2 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Abbas, Ghulam Shah, Shahid Hanif, Muhammad Shah, Abid Rehman, Anees ur Tahir, Sana Nayab, Komal Asghar, Arzoo The frequency of pulmonary hypertension in newborn with intrauterine growth restriction |
title | The frequency of pulmonary hypertension in newborn with intrauterine growth restriction |
title_full | The frequency of pulmonary hypertension in newborn with intrauterine growth restriction |
title_fullStr | The frequency of pulmonary hypertension in newborn with intrauterine growth restriction |
title_full_unstemmed | The frequency of pulmonary hypertension in newborn with intrauterine growth restriction |
title_short | The frequency of pulmonary hypertension in newborn with intrauterine growth restriction |
title_sort | frequency of pulmonary hypertension in newborn with intrauterine growth restriction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229189/ https://www.ncbi.nlm.nih.gov/pubmed/32415157 http://dx.doi.org/10.1038/s41598-020-65065-2 |
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