Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer

Abnormal regulation of β-catenin initiates an oncogenic program that serves as a main driver of many cancers. Albeit challenging, β-catenin is an attractive drug target due to its role in maintenance of cancer stem cells and potential to eliminate cancer relapse. We have identified C2, a novel β-cat...

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Detalles Bibliográficos
Autores principales: Cheltsov, Anton, Nomura, Natsuko, Yenugonda, Venkata M., Roper, Jatin, Mukthavaram, Rajesh, Jiang, Pengfei, Her, Nam-Gu, Babic, Ivan, Kesari, Santosh, Nurmemmedov, Elmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229215/
https://www.ncbi.nlm.nih.gov/pubmed/32415084
http://dx.doi.org/10.1038/s41598-020-60784-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229215/
https://www.ncbi.nlm.nih.gov/pubmed/32415084
http://dx.doi.org/10.1038/s41598-020-60784-y

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