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Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer
Abnormal regulation of β-catenin initiates an oncogenic program that serves as a main driver of many cancers. Albeit challenging, β-catenin is an attractive drug target due to its role in maintenance of cancer stem cells and potential to eliminate cancer relapse. We have identified C2, a novel β-cat...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229215/ https://www.ncbi.nlm.nih.gov/pubmed/32415084 http://dx.doi.org/10.1038/s41598-020-60784-y |