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N-alkylisatin-based microtubule destabilizers bind to the colchicine site on tubulin and retain efficacy in drug resistant acute lymphoblastic leukemia cell lines with less in vitro neurotoxicity

BACKGROUND: Drug resistance and chemotherapy-induced peripheral neuropathy continue to be significant problems in the successful treatment of acute lymphoblastic leukemia (ALL). 5,7-Dibromo-N-alkylisatins, a class of potent microtubule destabilizers, are a promising alternative to traditionally used...

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Detalles Bibliográficos
Autores principales:	Keenan, Bryce, Finol-Urdaneta, Rocio K., Hope, Ashleigh, Bremner, John B., Kavallaris, Maria, Lucena-Agell, Daniel, Oliva, María Ángela, Díaz, Jose Fernando, Vine, Kara L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229617/ https://www.ncbi.nlm.nih.gov/pubmed/32467666 http://dx.doi.org/10.1186/s12935-020-01251-6

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