NT-4 attenuates neuroinflammation via TrkB/PI3K/FoxO1 pathway after germinal matrix hemorrhage in neonatal rats

BACKGROUND: Neuroinflammation plays an important role in pathogenesis of germinal matrix hemorrhage (GMH). Neurotrophin-4 (NT-4) is a member of the neurotrophin family and interacts with the tropomyosin receptor kinase B (TrkB). NT-4 has been shown to confer neuroprotective effects following cerebra...

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Detalles Bibliográficos
Autores principales: Wang, Tianyi, Zhang, Junyi, Li, Peng, Ding, Yan, Tang, Jiping, Chen, Gang, Zhang, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229625/
https://www.ncbi.nlm.nih.gov/pubmed/32416727
http://dx.doi.org/10.1186/s12974-020-01835-z

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