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Hand sanitisers amid CoViD-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand

The world is facing a medical crisis amid the CoViD-19 pandemic and the role of adequate hygiene and hand sanitisers is inevitable in controlling the spread of infection in public places and healthcare institutions. There has been a great surge in demand for hand sanitisation products leading to sho...

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Autores principales: Berardi, Alberto, Perinelli, Diego R., Merchant, Hamid A., Bisharat, Lorina, Basheti, Iman A., Bonacucina, Giulia, Cespi, Marco, Palmieri, Giovanni F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229736/
https://www.ncbi.nlm.nih.gov/pubmed/32461194
http://dx.doi.org/10.1016/j.ijpharm.2020.119431
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author Berardi, Alberto
Perinelli, Diego R.
Merchant, Hamid A.
Bisharat, Lorina
Basheti, Iman A.
Bonacucina, Giulia
Cespi, Marco
Palmieri, Giovanni F.
author_facet Berardi, Alberto
Perinelli, Diego R.
Merchant, Hamid A.
Bisharat, Lorina
Basheti, Iman A.
Bonacucina, Giulia
Cespi, Marco
Palmieri, Giovanni F.
author_sort Berardi, Alberto
collection PubMed
description The world is facing a medical crisis amid the CoViD-19 pandemic and the role of adequate hygiene and hand sanitisers is inevitable in controlling the spread of infection in public places and healthcare institutions. There has been a great surge in demand for hand sanitisation products leading to shortages in their supply. A consequent increase of substandard products in the market has raised safety concerns. This article, therefore, presents a critical review of hand sanitation approaches and products available on the market in light of the scientific evidence available to date. This review also provides a range of hand sanitisation product formulations, and manufacturing instructions to allow for extemporaneous preparations at the community and hospital pharmacies during this urgent crisis. In addition, this emergent situation is expected to continue, hence hand sanitisers will be in demand for an extended time, and the availability and purchase of substandard products on the market create an ongoing safety concern. Therefore, this article shall also provide various commercial organisations, interested in stepping forward the production and marketing of hand sanitisers, with a guide on the development of products of standardised ingredients and formulations.
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spelling pubmed-72297362020-05-18 Hand sanitisers amid CoViD-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand Berardi, Alberto Perinelli, Diego R. Merchant, Hamid A. Bisharat, Lorina Basheti, Iman A. Bonacucina, Giulia Cespi, Marco Palmieri, Giovanni F. Int J Pharm Article The world is facing a medical crisis amid the CoViD-19 pandemic and the role of adequate hygiene and hand sanitisers is inevitable in controlling the spread of infection in public places and healthcare institutions. There has been a great surge in demand for hand sanitisation products leading to shortages in their supply. A consequent increase of substandard products in the market has raised safety concerns. This article, therefore, presents a critical review of hand sanitation approaches and products available on the market in light of the scientific evidence available to date. This review also provides a range of hand sanitisation product formulations, and manufacturing instructions to allow for extemporaneous preparations at the community and hospital pharmacies during this urgent crisis. In addition, this emergent situation is expected to continue, hence hand sanitisers will be in demand for an extended time, and the availability and purchase of substandard products on the market create an ongoing safety concern. Therefore, this article shall also provide various commercial organisations, interested in stepping forward the production and marketing of hand sanitisers, with a guide on the development of products of standardised ingredients and formulations. Elsevier B.V. 2020-06-30 2020-05-16 /pmc/articles/PMC7229736/ /pubmed/32461194 http://dx.doi.org/10.1016/j.ijpharm.2020.119431 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Berardi, Alberto
Perinelli, Diego R.
Merchant, Hamid A.
Bisharat, Lorina
Basheti, Iman A.
Bonacucina, Giulia
Cespi, Marco
Palmieri, Giovanni F.
Hand sanitisers amid CoViD-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand
title Hand sanitisers amid CoViD-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand
title_full Hand sanitisers amid CoViD-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand
title_fullStr Hand sanitisers amid CoViD-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand
title_full_unstemmed Hand sanitisers amid CoViD-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand
title_short Hand sanitisers amid CoViD-19: A critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand
title_sort hand sanitisers amid covid-19: a critical review of alcohol-based products on the market and formulation approaches to respond to increasing demand
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229736/
https://www.ncbi.nlm.nih.gov/pubmed/32461194
http://dx.doi.org/10.1016/j.ijpharm.2020.119431
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