Cargando…

Berberine Induces Autophagic Cell Death in Acute Lymphoblastic Leukemia by Inactivating AKT/mTORC1 Signaling

INTRODUCTION: Berberine has been reported to inhibit cancer cell growth by apoptosis induction and exhibits a protective role against cancer progression. The current study aims to investigate the effects of berberine on acute lymphoblastic leukemia (ALL) and the mechanism beyond apoptosis. METHODS:...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Jian, Liu, Peng, Xu, Tiantian, Chen, Zhiwei, Kong, Huimin, Chu, Weihong, Wang, Yingchao, Liu, Yufeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229801/ https://www.ncbi.nlm.nih.gov/pubmed/32494123 http://dx.doi.org/10.2147/DDDT.S239247

Ejemplares similares

Berberine promotes XIAP-mediated cells apoptosis by upregulation of miR-24-3p in acute lymphoblastic leukemia
por: Liu, Jian, et al.
Publicado: (2020)

SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt
por: Meng, Haitao, et al.
Publicado: (2013)

Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission
por: McCabe, Matthew P, et al.
Publicado: (2020)

CBAP modulates Akt-dependent TSC2 phosphorylation to promote Rheb-mTORC1 signaling and growth of T-cell acute lymphoblastic leukemia
por: Chiang, Yun-Jung, et al.
Publicado: (2018)

Berberine Protects Mice Against Dextran Sulfate Sodium-Induced Colitis by Activating mTORC1 Pathway
por: Li, Qingjun, et al.
Publicado: (2019)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
por: Miao, Linqing, et al.
Publicado: (2016)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Efficacy of a Novel Bi-Steric mTORC1 Inhibitor in Models of B-Cell Acute Lymphoblastic Leukemia
por: Lee, Bianca J., et al.
Publicado: (2021)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells
por: Wang, Chenran, et al.
Publicado: (2019)

High glutamine suppresses osteogenesis through mTORC1-mediated inhibition of the mTORC2/AKT-473/RUNX2 axis
por: Gayatri, Meher Bolisetti, et al.
Publicado: (2022)

TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1
por: Plescher, Monika, et al.
Publicado: (2015)

Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T‐cell leukemia
por: Kawata, Takahito, et al.
Publicado: (2017)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
por: Weinberg, Mark A.
Publicado: (2016)

Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation
por: Chen, Yingji, et al.
Publicado: (2023)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells
por: Joha, S, et al.
Publicado: (2012)

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2
por: Humphrey, Sean J., et al.
Publicado: (2013)

Role of AKT/mTORC1 pathway in pancreatic β-cell proliferation.
por: Balcazar Morales, Norman, et al.
Publicado: (2012)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Translationally controlled tumor protein promotes liver regeneration by activating mTORC2/AKT signaling
por: Lin, Zhibin, et al.
Publicado: (2020)

Uropathogenic Escherichia coli Infection Compromises the Blood-Testis Barrier by Disturbing mTORC1-mTORC2 Balance
por: Lu, Yongning, et al.
Publicado: (2021)

Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
por: He, Chang-Liang, et al.
Publicado: (2016)

The expression and significance of mTORC1 in diabetic retinopathy
por: Liu, Yanli, et al.
Publicado: (2020)

Artemin Promotes the Migration and Invasion of Cervical Cancer Cells through AKT/mTORC1 Signaling
por: Zhu, Mengjing, et al.
Publicado: (2022)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1
por: Du, Heng, et al.
Publicado: (2023)

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
por: Porstmann, Thomas, et al.
Publicado: (2008)

Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
por: Zhang, Hui H., et al.
Publicado: (2009)

Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma
por: Ronellenfitsch, Michael W., et al.
Publicado: (2018)

mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis
por: Martinez, Nuria, et al.
Publicado: (2019)

TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling
por: Salazar, María, et al.
Publicado: (2015)

Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus
por: Zhou, Xin, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_suv3fn6o9lclck54agbjn8giig