Deacetylase-independent function of SIRT6 couples GATA4 transcription factor and epigenetic activation against cardiomyocyte apoptosis

SIRT6 deacetylase activity improves stress resistance via gene silencing and genome maintenance. Here, we reveal a deacetylase-independent function of SIRT6, which promotes anti-apoptotic gene expression via the transcription factor GATA4. SIRT6 recruits TIP60 acetyltransferase to acetylate GATA4 at...

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Detalles Bibliográficos
Autores principales: Peng, Linyuan, Qian, Minxian, Liu, Zuojun, Tang, Xiaolong, Sun, Jie, Jiang, Yue, Sun, Shimin, Cao, Xinyue, Pang, Qiuxiang, Liu, Baohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229816/
https://www.ncbi.nlm.nih.gov/pubmed/32239217
http://dx.doi.org/10.1093/nar/gkaa214

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