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Effect of 2′-5′/3′-5′ phosphodiester linkage heterogeneity on RNA interference

We report on the synthesis of siRNAs containing both 2′-5′- and 3′-5′-internucleotide linkages and their effects on siRNA structure, function, and interaction with RNAi proteins. Screening of these siRNAs against their corresponding mRNA targets showed that 2′-5′ linkages were well tolerated in the...

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Detalles Bibliográficos
Autores principales:	Habibian, Maryam, Harikrishna, S, Fakhoury, Johans, Barton, Maria, Ageely, Eman A, Cencic, Regina, Fakih, Hassan H, Katolik, Adam, Takahashi, Mayumi, Rossi, John, Pelletier, Jerry, Gagnon, Keith T, Pradeepkumar, P I, Damha, Masad J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229817/ https://www.ncbi.nlm.nih.gov/pubmed/32282904 http://dx.doi.org/10.1093/nar/gkaa222

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