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Human POT1 unfolds G-quadruplexes by conformational selection
The reaction mechanism by which the shelterin protein POT1 (Protection of Telomeres 1) unfolds human telomeric G-quadruplex structures is not fully understood. We report here kinetic, thermodynamic, hydrodynamic and computational studies that show that a conformational selection mechanism, in which...
Autores principales: | Chaires, Jonathan B, Gray, Robert D, Dean, William L, Monsen, Robert, DeLeeuw, Lynn W, Stribinskis, Vilius, Trent, John O |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229828/ https://www.ncbi.nlm.nih.gov/pubmed/32232414 http://dx.doi.org/10.1093/nar/gkaa202 |
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