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Human POT1 unfolds G-quadruplexes by conformational selection

The reaction mechanism by which the shelterin protein POT1 (Protection of Telomeres 1) unfolds human telomeric G-quadruplex structures is not fully understood. We report here kinetic, thermodynamic, hydrodynamic and computational studies that show that a conformational selection mechanism, in which...

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Detalles Bibliográficos
Autores principales:	Chaires, Jonathan B, Gray, Robert D, Dean, William L, Monsen, Robert, DeLeeuw, Lynn W, Stribinskis, Vilius, Trent, John O
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229828/ https://www.ncbi.nlm.nih.gov/pubmed/32232414 http://dx.doi.org/10.1093/nar/gkaa202

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