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Global and local mechanical properties control endonuclease reactivity of a DNA origami nanostructure

We used coarse-grained molecular dynamics simulations to characterize the global and local mechanical properties of a DNA origami triangle nanostructure. The structure presents two metastable conformations separated by a free energy barrier that is lowered upon omission of four specific DNA staples...

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Detalles Bibliográficos
Autores principales:	Suma, Antonio, Stopar, Alex, Nicholson, Allen W, Castronovo, Matteo, Carnevale, Vincenzo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229852/ https://www.ncbi.nlm.nih.gov/pubmed/32043111 http://dx.doi.org/10.1093/nar/gkaa080

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