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Differential modulation of the androgen receptor for prostate cancer therapy depends on the DNA response element

Androgen receptor (AR) action is a hallmark of prostate cancer (PCa) with androgen deprivation being standard therapy. Yet, resistance arises and aberrant AR signaling promotes disease. We sought compounds that inhibited genes driving cancer but not normal growth and hypothesized that genes with con...

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Detalles Bibliográficos
Autores principales:	Kregel, Steven, Bagamasbad, Pia, He, Shihan, LaPensee, Elizabeth, Raji, Yemi, Brogley, Michele, Chinnaiyan, Arul, Cieslik, Marcin, Robins, Diane M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229860/ https://www.ncbi.nlm.nih.gov/pubmed/32198885 http://dx.doi.org/10.1093/nar/gkaa178

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