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Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine

Reactive oxygen species generate the genotoxic 8-oxoguanine (oxoG) and 8-oxoadenine (oxoA) as major oxidative lesions. The mutagenicity of oxoG is attributed to the lesion's ability to evade the geometric discrimination of DNA polymerases by adopting Hoogsteen base pairing with adenine in a Wat...

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Detalles Bibliográficos
Autores principales:	Koag, Myong-Chul, Jung, Hunmin, Lee, Seongmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229865/ https://www.ncbi.nlm.nih.gov/pubmed/32282906 http://dx.doi.org/10.1093/nar/gkaa193

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