Identification of PP2A and S6 Kinase as Modifiers of Leucine-Rich Repeat Kinase-Induced Neurotoxicity

Mutations in LRRK2 are currently recognized as the most common monogenetic cause of Parkinsonism. The elevation of kinase activity of LRRK2 that frequently accompanies its mutations is widely thought to contribute to its toxicity. Accordingly, many groups have developed LRRK2-specific kinase inhibit...

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Detalles Bibliográficos
Autores principales: Sim, Joan Poh Ling, Ziyin, Wang, Basil, Adeline Henry, Lin, Shuping, Chen, Zhongcan, Zhang, Chengwu, Zeng, Li, Cai, Yu, Lim, Kah-Leong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230064/
https://www.ncbi.nlm.nih.gov/pubmed/31664682
http://dx.doi.org/10.1007/s12017-019-08577-z

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