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Enterovirus-Human Rhinovirus as a Leading Cause of ARDS in a Liver Transplant Recipient

A 35- year- old man with a prior history of liver transplantation 18 months ago was admitted to our Intensive Care Unit (ICU) with fever and worsening dyspnea and was diagnosed with severe pneumonia leading to Acute Respiratory Distress Syndrome (ARDS). He had a prolonged hospitalization and was tre...

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Autores principales: Yousefi, Meysam, Nadji, Seyed Alireza, Farzanegan, Behrooz, Hashemian, Seyed Mohammad Reza, Marjani, Majid, Moniri, Afshin, Javanmard, Pedram, Tabarsi, Payam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Research Institute of Tuberculosis and Lung Disease 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230127/
https://www.ncbi.nlm.nih.gov/pubmed/32440306
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author Yousefi, Meysam
Nadji, Seyed Alireza
Farzanegan, Behrooz
Hashemian, Seyed Mohammad Reza
Marjani, Majid
Moniri, Afshin
Javanmard, Pedram
Tabarsi, Payam
author_facet Yousefi, Meysam
Nadji, Seyed Alireza
Farzanegan, Behrooz
Hashemian, Seyed Mohammad Reza
Marjani, Majid
Moniri, Afshin
Javanmard, Pedram
Tabarsi, Payam
author_sort Yousefi, Meysam
collection PubMed
description A 35- year- old man with a prior history of liver transplantation 18 months ago was admitted to our Intensive Care Unit (ICU) with fever and worsening dyspnea and was diagnosed with severe pneumonia leading to Acute Respiratory Distress Syndrome (ARDS). He had a prolonged hospitalization and was treated with empiric broad spectrum intravenous antibiotics, oseltamivir, trimethoprim/sulfamethoxazole, and subsequently caspofungin and ganciclovir. Blood, nasopharyngeal, as well as Bronchoalveolar Lavage (BAL) culture and Polymerase Chain Reaction (PCR) were negative for all viral, bacterial, and fungal causes of pulmonary infection except Enterovirus-Human Rhinovirus (EV-HRV) that was positive with high titers on BAL and swab specimens. Consequently, the diagnosis of EV-HRV pneumonia complicated by ARDS was established. The patient gradually improved and was discharged from the hospital after 3 weeks. This report highlights EV-HRV as a cause of ARDS in immunocompromised adults.
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spelling pubmed-72301272020-05-21 Enterovirus-Human Rhinovirus as a Leading Cause of ARDS in a Liver Transplant Recipient Yousefi, Meysam Nadji, Seyed Alireza Farzanegan, Behrooz Hashemian, Seyed Mohammad Reza Marjani, Majid Moniri, Afshin Javanmard, Pedram Tabarsi, Payam Tanaffos Case Report A 35- year- old man with a prior history of liver transplantation 18 months ago was admitted to our Intensive Care Unit (ICU) with fever and worsening dyspnea and was diagnosed with severe pneumonia leading to Acute Respiratory Distress Syndrome (ARDS). He had a prolonged hospitalization and was treated with empiric broad spectrum intravenous antibiotics, oseltamivir, trimethoprim/sulfamethoxazole, and subsequently caspofungin and ganciclovir. Blood, nasopharyngeal, as well as Bronchoalveolar Lavage (BAL) culture and Polymerase Chain Reaction (PCR) were negative for all viral, bacterial, and fungal causes of pulmonary infection except Enterovirus-Human Rhinovirus (EV-HRV) that was positive with high titers on BAL and swab specimens. Consequently, the diagnosis of EV-HRV pneumonia complicated by ARDS was established. The patient gradually improved and was discharged from the hospital after 3 weeks. This report highlights EV-HRV as a cause of ARDS in immunocompromised adults. National Research Institute of Tuberculosis and Lung Disease 2019-02 /pmc/articles/PMC7230127/ /pubmed/32440306 Text en Copyright© 2019 National Research Institute of Tuberculosis and Lung Disease http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Yousefi, Meysam
Nadji, Seyed Alireza
Farzanegan, Behrooz
Hashemian, Seyed Mohammad Reza
Marjani, Majid
Moniri, Afshin
Javanmard, Pedram
Tabarsi, Payam
Enterovirus-Human Rhinovirus as a Leading Cause of ARDS in a Liver Transplant Recipient
title Enterovirus-Human Rhinovirus as a Leading Cause of ARDS in a Liver Transplant Recipient
title_full Enterovirus-Human Rhinovirus as a Leading Cause of ARDS in a Liver Transplant Recipient
title_fullStr Enterovirus-Human Rhinovirus as a Leading Cause of ARDS in a Liver Transplant Recipient
title_full_unstemmed Enterovirus-Human Rhinovirus as a Leading Cause of ARDS in a Liver Transplant Recipient
title_short Enterovirus-Human Rhinovirus as a Leading Cause of ARDS in a Liver Transplant Recipient
title_sort enterovirus-human rhinovirus as a leading cause of ards in a liver transplant recipient
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230127/
https://www.ncbi.nlm.nih.gov/pubmed/32440306
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