A New Customized Bioactive Glass Filler to Functionalize Resin Composites: Acid-Neutralizing Capability, Degree of Conversion, and Apatite Precipitation

This study introduced an experimental bioactive glass (BG) with a lower Na(2)O content than conventional BG 45S5 (10.5 wt% vs. 24.5 wt%), additionally containing CaF(2) (12 wt%) and a network connectivity similar to that of BG 45S5. A series of experimental composites functionalized with 5–40 wt% of the novel BG was prepared and compared to a corresponding series of experimental composites functionalized with 5–40 wt% of BG 45S5. Commercial acid-neutralizing materials (alkasite, giomer, and glass ionomer) were used as references. The capabilities of the materials to neutralize hydrochloric acid (pH = 2.6) and lactic acid (pH = 4.5) were evaluated by real-time pH measurements over 1 h. The degree of conversion and precipitation of calcium phosphate were also investigated. Data were analyzed using one-way and Welch ANOVA at an overall level of significance of 0.05. The acid-neutralizing potential of the experimental BG incorporated into resin composites was generally comparable to that of BG 45S5, and better than that of a giomer and glass ionomer. Fluorine was identified in the precipitate that developed on the composites functionalized with the experimental BG, suggesting a capability of forming fluorapatite. Unlike the 45S5 composition, the experimental BG did not impair the degree of conversion of resin composites. The novel BG filler is therefore an interesting candidate for future investigations of caries-preventive resin composites, and their potential clinical applicability for restorative, preventive, and orthodontic purposes.