Active Pulmonary Tuberculosis Triggered by Interferon Beta-1b Therapy of Multiple Sclerosis: Four Case Reports and a Literature Review

In this paper, we reported on four cases of severe pulmonary active tuberculosis in patients with multiple sclerosis (MS) undergoing interferon beta-1b (IFNβ-1b) therapy. Disease-modifying therapies (DMTs) in MS may increase the risk of developing active tuberculosis (TB) due to their impact on cell...

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Detalles Bibliográficos
Autores principales: Sirbu, Carmen Adella, Dantes, Elena, Plesa, Cristina Florentina, Docu Axelerad, Any, Ghinescu, Minerva Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230182/
https://www.ncbi.nlm.nih.gov/pubmed/32344653
http://dx.doi.org/10.3390/medicina56040202
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author Sirbu, Carmen Adella
Dantes, Elena
Plesa, Cristina Florentina
Docu Axelerad, Any
Ghinescu, Minerva Claudia
author_facet Sirbu, Carmen Adella
Dantes, Elena
Plesa, Cristina Florentina
Docu Axelerad, Any
Ghinescu, Minerva Claudia
author_sort Sirbu, Carmen Adella
collection PubMed
description In this paper, we reported on four cases of severe pulmonary active tuberculosis in patients with multiple sclerosis (MS) undergoing interferon beta-1b (IFNβ-1b) therapy. Disease-modifying therapies (DMTs) in MS may increase the risk of developing active tuberculosis (TB) due to their impact on cellular immunity. Screening for latent infection with Mycobacterium tuberculosis (LTBI) should be performed, not only for the newer DMTs (alemtuzumab, ocrelizumab) but also for IFNβ-1b, alongside better supervision of these patients.
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spelling pubmed-72301822020-05-28 Active Pulmonary Tuberculosis Triggered by Interferon Beta-1b Therapy of Multiple Sclerosis: Four Case Reports and a Literature Review Sirbu, Carmen Adella Dantes, Elena Plesa, Cristina Florentina Docu Axelerad, Any Ghinescu, Minerva Claudia Medicina (Kaunas) Case Report In this paper, we reported on four cases of severe pulmonary active tuberculosis in patients with multiple sclerosis (MS) undergoing interferon beta-1b (IFNβ-1b) therapy. Disease-modifying therapies (DMTs) in MS may increase the risk of developing active tuberculosis (TB) due to their impact on cellular immunity. Screening for latent infection with Mycobacterium tuberculosis (LTBI) should be performed, not only for the newer DMTs (alemtuzumab, ocrelizumab) but also for IFNβ-1b, alongside better supervision of these patients. MDPI 2020-04-24 /pmc/articles/PMC7230182/ /pubmed/32344653 http://dx.doi.org/10.3390/medicina56040202 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Sirbu, Carmen Adella
Dantes, Elena
Plesa, Cristina Florentina
Docu Axelerad, Any
Ghinescu, Minerva Claudia
Active Pulmonary Tuberculosis Triggered by Interferon Beta-1b Therapy of Multiple Sclerosis: Four Case Reports and a Literature Review
title Active Pulmonary Tuberculosis Triggered by Interferon Beta-1b Therapy of Multiple Sclerosis: Four Case Reports and a Literature Review
title_full Active Pulmonary Tuberculosis Triggered by Interferon Beta-1b Therapy of Multiple Sclerosis: Four Case Reports and a Literature Review
title_fullStr Active Pulmonary Tuberculosis Triggered by Interferon Beta-1b Therapy of Multiple Sclerosis: Four Case Reports and a Literature Review
title_full_unstemmed Active Pulmonary Tuberculosis Triggered by Interferon Beta-1b Therapy of Multiple Sclerosis: Four Case Reports and a Literature Review
title_short Active Pulmonary Tuberculosis Triggered by Interferon Beta-1b Therapy of Multiple Sclerosis: Four Case Reports and a Literature Review
title_sort active pulmonary tuberculosis triggered by interferon beta-1b therapy of multiple sclerosis: four case reports and a literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230182/
https://www.ncbi.nlm.nih.gov/pubmed/32344653
http://dx.doi.org/10.3390/medicina56040202
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