Cargando…

Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study

Objectives: To explore the effect of breakthrough cancer pain (BTcP) treatment on quality of sleep and other aspects of the health-related quality of life (HRQoL) in patients with cancer pain. Methods: In an observational, multicenter, cohort study, cancer patients from palliative care units, oncolo...

Descripción completa

Detalles Bibliográficos
Autores principales: Cuomo, Arturo, Cascella, Marco, Forte, Cira Antonietta, Bimonte, Sabrina, Esposito, Gennaro, De Santis, Stefano, Cavanna, Luigi, Fusco, Flavio, Dauri, Mario, Natoli, Silvia, Maltoni, Marco, Morabito, Alessandro, Mediati, Rocco Domenico, Lorusso, Vito, Barni, Sandro, Porzio, Giampiero, Mercadante, Sebastiano, Crispo, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230287/
https://www.ncbi.nlm.nih.gov/pubmed/32252426
http://dx.doi.org/10.3390/jcm9041003
_version_ 1783534914599124992
author Cuomo, Arturo
Cascella, Marco
Forte, Cira Antonietta
Bimonte, Sabrina
Esposito, Gennaro
De Santis, Stefano
Cavanna, Luigi
Fusco, Flavio
Dauri, Mario
Natoli, Silvia
Maltoni, Marco
Morabito, Alessandro
Mediati, Rocco Domenico
Lorusso, Vito
Barni, Sandro
Porzio, Giampiero
Mercadante, Sebastiano
Crispo, Anna
author_facet Cuomo, Arturo
Cascella, Marco
Forte, Cira Antonietta
Bimonte, Sabrina
Esposito, Gennaro
De Santis, Stefano
Cavanna, Luigi
Fusco, Flavio
Dauri, Mario
Natoli, Silvia
Maltoni, Marco
Morabito, Alessandro
Mediati, Rocco Domenico
Lorusso, Vito
Barni, Sandro
Porzio, Giampiero
Mercadante, Sebastiano
Crispo, Anna
author_sort Cuomo, Arturo
collection PubMed
description Objectives: To explore the effect of breakthrough cancer pain (BTcP) treatment on quality of sleep and other aspects of the health-related quality of life (HRQoL) in patients with cancer pain. Methods: In an observational, multicenter, cohort study, cancer patients from palliative care units, oncology departments, and pain clinics and affected by BTcP were included. Enrolled patients were assessed at the four visits: T0 (baseline), T7, T14, and T28. Stable chronic background pain (numeric rating scale, NRS ≤ 4) during the whole study period was mandatory. BTcP was treated through transmucosal fentanyl. Three questionnaires were used to measure the HRQoL: EORTC QLQ-C15-PAL, Pittsburgh Sleep Quality Index (PSQI), and the Edmonton Symptom Assessment System (ESAS). RESULTS: In 154 patients, the HRQoL showed a significant improvement for all physical and emotional characteristics in the EORTC QLQ-C15-PAL, except for nausea and vomiting (linear p-value = 0.1) and dyspnea (Linear p-value = 0.05). The ESAS and PSQI questionnaires confirmed these positive results (p < 0.0001 and p = 0.002, respectively). Conclusions: This prospective investigation by an Italian expert group, has confirmed that careful management of BTcP induces a paramount improvement on the HRQoL. Because in cancer patients there is a high prevalence of BTcP and this severe acute pain has deleterious consequences, this information can have an important clinical significance.
format Online
Article
Text
id pubmed-7230287
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72302872020-05-28 Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study Cuomo, Arturo Cascella, Marco Forte, Cira Antonietta Bimonte, Sabrina Esposito, Gennaro De Santis, Stefano Cavanna, Luigi Fusco, Flavio Dauri, Mario Natoli, Silvia Maltoni, Marco Morabito, Alessandro Mediati, Rocco Domenico Lorusso, Vito Barni, Sandro Porzio, Giampiero Mercadante, Sebastiano Crispo, Anna J Clin Med Article Objectives: To explore the effect of breakthrough cancer pain (BTcP) treatment on quality of sleep and other aspects of the health-related quality of life (HRQoL) in patients with cancer pain. Methods: In an observational, multicenter, cohort study, cancer patients from palliative care units, oncology departments, and pain clinics and affected by BTcP were included. Enrolled patients were assessed at the four visits: T0 (baseline), T7, T14, and T28. Stable chronic background pain (numeric rating scale, NRS ≤ 4) during the whole study period was mandatory. BTcP was treated through transmucosal fentanyl. Three questionnaires were used to measure the HRQoL: EORTC QLQ-C15-PAL, Pittsburgh Sleep Quality Index (PSQI), and the Edmonton Symptom Assessment System (ESAS). RESULTS: In 154 patients, the HRQoL showed a significant improvement for all physical and emotional characteristics in the EORTC QLQ-C15-PAL, except for nausea and vomiting (linear p-value = 0.1) and dyspnea (Linear p-value = 0.05). The ESAS and PSQI questionnaires confirmed these positive results (p < 0.0001 and p = 0.002, respectively). Conclusions: This prospective investigation by an Italian expert group, has confirmed that careful management of BTcP induces a paramount improvement on the HRQoL. Because in cancer patients there is a high prevalence of BTcP and this severe acute pain has deleterious consequences, this information can have an important clinical significance. MDPI 2020-04-02 /pmc/articles/PMC7230287/ /pubmed/32252426 http://dx.doi.org/10.3390/jcm9041003 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cuomo, Arturo
Cascella, Marco
Forte, Cira Antonietta
Bimonte, Sabrina
Esposito, Gennaro
De Santis, Stefano
Cavanna, Luigi
Fusco, Flavio
Dauri, Mario
Natoli, Silvia
Maltoni, Marco
Morabito, Alessandro
Mediati, Rocco Domenico
Lorusso, Vito
Barni, Sandro
Porzio, Giampiero
Mercadante, Sebastiano
Crispo, Anna
Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study
title Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study
title_full Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study
title_fullStr Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study
title_full_unstemmed Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study
title_short Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study
title_sort careful breakthrough cancer pain treatment through rapid-onset transmucosal fentanyl improves the quality of life in cancer patients: results from the best multicenter study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230287/
https://www.ncbi.nlm.nih.gov/pubmed/32252426
http://dx.doi.org/10.3390/jcm9041003
work_keys_str_mv AT cuomoarturo carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT cascellamarco carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT forteciraantonietta carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT bimontesabrina carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT espositogennaro carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT desantisstefano carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT cavannaluigi carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT fuscoflavio carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT daurimario carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT natolisilvia carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT maltonimarco carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT morabitoalessandro carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT mediatiroccodomenico carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT lorussovito carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT barnisandro carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT porziogiampiero carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT mercadantesebastiano carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy
AT crispoanna carefulbreakthroughcancerpaintreatmentthroughrapidonsettransmucosalfentanylimprovesthequalityoflifeincancerpatientsresultsfromthebestmulticenterstudy