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Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study
Objectives: To explore the effect of breakthrough cancer pain (BTcP) treatment on quality of sleep and other aspects of the health-related quality of life (HRQoL) in patients with cancer pain. Methods: In an observational, multicenter, cohort study, cancer patients from palliative care units, oncolo...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230287/ https://www.ncbi.nlm.nih.gov/pubmed/32252426 http://dx.doi.org/10.3390/jcm9041003 |
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author | Cuomo, Arturo Cascella, Marco Forte, Cira Antonietta Bimonte, Sabrina Esposito, Gennaro De Santis, Stefano Cavanna, Luigi Fusco, Flavio Dauri, Mario Natoli, Silvia Maltoni, Marco Morabito, Alessandro Mediati, Rocco Domenico Lorusso, Vito Barni, Sandro Porzio, Giampiero Mercadante, Sebastiano Crispo, Anna |
author_facet | Cuomo, Arturo Cascella, Marco Forte, Cira Antonietta Bimonte, Sabrina Esposito, Gennaro De Santis, Stefano Cavanna, Luigi Fusco, Flavio Dauri, Mario Natoli, Silvia Maltoni, Marco Morabito, Alessandro Mediati, Rocco Domenico Lorusso, Vito Barni, Sandro Porzio, Giampiero Mercadante, Sebastiano Crispo, Anna |
author_sort | Cuomo, Arturo |
collection | PubMed |
description | Objectives: To explore the effect of breakthrough cancer pain (BTcP) treatment on quality of sleep and other aspects of the health-related quality of life (HRQoL) in patients with cancer pain. Methods: In an observational, multicenter, cohort study, cancer patients from palliative care units, oncology departments, and pain clinics and affected by BTcP were included. Enrolled patients were assessed at the four visits: T0 (baseline), T7, T14, and T28. Stable chronic background pain (numeric rating scale, NRS ≤ 4) during the whole study period was mandatory. BTcP was treated through transmucosal fentanyl. Three questionnaires were used to measure the HRQoL: EORTC QLQ-C15-PAL, Pittsburgh Sleep Quality Index (PSQI), and the Edmonton Symptom Assessment System (ESAS). RESULTS: In 154 patients, the HRQoL showed a significant improvement for all physical and emotional characteristics in the EORTC QLQ-C15-PAL, except for nausea and vomiting (linear p-value = 0.1) and dyspnea (Linear p-value = 0.05). The ESAS and PSQI questionnaires confirmed these positive results (p < 0.0001 and p = 0.002, respectively). Conclusions: This prospective investigation by an Italian expert group, has confirmed that careful management of BTcP induces a paramount improvement on the HRQoL. Because in cancer patients there is a high prevalence of BTcP and this severe acute pain has deleterious consequences, this information can have an important clinical significance. |
format | Online Article Text |
id | pubmed-7230287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72302872020-05-28 Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study Cuomo, Arturo Cascella, Marco Forte, Cira Antonietta Bimonte, Sabrina Esposito, Gennaro De Santis, Stefano Cavanna, Luigi Fusco, Flavio Dauri, Mario Natoli, Silvia Maltoni, Marco Morabito, Alessandro Mediati, Rocco Domenico Lorusso, Vito Barni, Sandro Porzio, Giampiero Mercadante, Sebastiano Crispo, Anna J Clin Med Article Objectives: To explore the effect of breakthrough cancer pain (BTcP) treatment on quality of sleep and other aspects of the health-related quality of life (HRQoL) in patients with cancer pain. Methods: In an observational, multicenter, cohort study, cancer patients from palliative care units, oncology departments, and pain clinics and affected by BTcP were included. Enrolled patients were assessed at the four visits: T0 (baseline), T7, T14, and T28. Stable chronic background pain (numeric rating scale, NRS ≤ 4) during the whole study period was mandatory. BTcP was treated through transmucosal fentanyl. Three questionnaires were used to measure the HRQoL: EORTC QLQ-C15-PAL, Pittsburgh Sleep Quality Index (PSQI), and the Edmonton Symptom Assessment System (ESAS). RESULTS: In 154 patients, the HRQoL showed a significant improvement for all physical and emotional characteristics in the EORTC QLQ-C15-PAL, except for nausea and vomiting (linear p-value = 0.1) and dyspnea (Linear p-value = 0.05). The ESAS and PSQI questionnaires confirmed these positive results (p < 0.0001 and p = 0.002, respectively). Conclusions: This prospective investigation by an Italian expert group, has confirmed that careful management of BTcP induces a paramount improvement on the HRQoL. Because in cancer patients there is a high prevalence of BTcP and this severe acute pain has deleterious consequences, this information can have an important clinical significance. MDPI 2020-04-02 /pmc/articles/PMC7230287/ /pubmed/32252426 http://dx.doi.org/10.3390/jcm9041003 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cuomo, Arturo Cascella, Marco Forte, Cira Antonietta Bimonte, Sabrina Esposito, Gennaro De Santis, Stefano Cavanna, Luigi Fusco, Flavio Dauri, Mario Natoli, Silvia Maltoni, Marco Morabito, Alessandro Mediati, Rocco Domenico Lorusso, Vito Barni, Sandro Porzio, Giampiero Mercadante, Sebastiano Crispo, Anna Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study |
title | Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study |
title_full | Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study |
title_fullStr | Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study |
title_full_unstemmed | Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study |
title_short | Careful Breakthrough Cancer Pain Treatment through Rapid-Onset Transmucosal Fentanyl Improves the Quality of Life in Cancer Patients: Results from the BEST Multicenter Study |
title_sort | careful breakthrough cancer pain treatment through rapid-onset transmucosal fentanyl improves the quality of life in cancer patients: results from the best multicenter study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230287/ https://www.ncbi.nlm.nih.gov/pubmed/32252426 http://dx.doi.org/10.3390/jcm9041003 |
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