Linezolid Concentrations in Plasma and Subcutaneous Tissue are Reduced in Obese Patients, Resulting in a Higher Risk of Underdosing in Critically Ill Patients: A Controlled Clinical Pharmacokinetic Study

Background: Linezolid is used for the treatment of soft tissue infections in critically ill patients. However, data for characterizing the pharmacokinetics (PK) and assessing whether effective concentrations are reached at the target site are lacking. We hypothesized that current dosing regimens do...

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Detalles Bibliográficos
Autores principales: Simon, Philipp, Busse, David, Petroff, David, Dorn, Christoph, Ehmann, Lisa, Hochstädt, Sophie, Girrbach, Felix, Dietrich, Arne, Zeitlinger, Markus, Kees, Frieder, Kloft, Charlotte, Wrigge, Hermann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230366/
https://www.ncbi.nlm.nih.gov/pubmed/32283731
http://dx.doi.org/10.3390/jcm9041067

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