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Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential

Lung cancer is one of the major causes of death worldwide. Natural molecules with anti-lung cancer potential are of a great interest and considered as very promising alternative to substitute or enhance the efficiency of the conventional drugs. Recently, algae as source of high value-added compounds...

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Autores principales: Saadaoui, Imen, Rasheed, Rihab, Abdulrahman, Nabeel, Bounnit, Touria, Cherif, Maroua, Al Jabri, Hareb, Mraiche, Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230368/
https://www.ncbi.nlm.nih.gov/pubmed/32276401
http://dx.doi.org/10.3390/md18040197
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author Saadaoui, Imen
Rasheed, Rihab
Abdulrahman, Nabeel
Bounnit, Touria
Cherif, Maroua
Al Jabri, Hareb
Mraiche, Fatima
author_facet Saadaoui, Imen
Rasheed, Rihab
Abdulrahman, Nabeel
Bounnit, Touria
Cherif, Maroua
Al Jabri, Hareb
Mraiche, Fatima
author_sort Saadaoui, Imen
collection PubMed
description Lung cancer is one of the major causes of death worldwide. Natural molecules with anti-lung cancer potential are of a great interest and considered as very promising alternative to substitute or enhance the efficiency of the conventional drugs. Recently, algae as source of high value-added compounds are considered as very promising source of these bioactive molecules. These are secondary metabolites that consist mainly of derivatives of peptides, carbohydrates, and lipids with various structures. Accordingly, various mechanisms by which different algae molecules demonstrate attenuation of tumor angiogenesis were stated and discussed. The mode of action of the algae bioactives is closely related to their nature and chemical structure. Furthermore, this literature review considers the synergistic effect between microalgae bioactives and conventional drugs and discuss the economic feasibility of producing microalgae bioactives at large scale to conclude with some future perspectives related to algae-based drug discovery.
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spelling pubmed-72303682020-05-22 Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential Saadaoui, Imen Rasheed, Rihab Abdulrahman, Nabeel Bounnit, Touria Cherif, Maroua Al Jabri, Hareb Mraiche, Fatima Mar Drugs Review Lung cancer is one of the major causes of death worldwide. Natural molecules with anti-lung cancer potential are of a great interest and considered as very promising alternative to substitute or enhance the efficiency of the conventional drugs. Recently, algae as source of high value-added compounds are considered as very promising source of these bioactive molecules. These are secondary metabolites that consist mainly of derivatives of peptides, carbohydrates, and lipids with various structures. Accordingly, various mechanisms by which different algae molecules demonstrate attenuation of tumor angiogenesis were stated and discussed. The mode of action of the algae bioactives is closely related to their nature and chemical structure. Furthermore, this literature review considers the synergistic effect between microalgae bioactives and conventional drugs and discuss the economic feasibility of producing microalgae bioactives at large scale to conclude with some future perspectives related to algae-based drug discovery. MDPI 2020-04-08 /pmc/articles/PMC7230368/ /pubmed/32276401 http://dx.doi.org/10.3390/md18040197 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saadaoui, Imen
Rasheed, Rihab
Abdulrahman, Nabeel
Bounnit, Touria
Cherif, Maroua
Al Jabri, Hareb
Mraiche, Fatima
Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential
title Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential
title_full Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential
title_fullStr Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential
title_full_unstemmed Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential
title_short Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential
title_sort algae-derived bioactive compounds with anti-lung cancer potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230368/
https://www.ncbi.nlm.nih.gov/pubmed/32276401
http://dx.doi.org/10.3390/md18040197
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