Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases

Health can be defined as a harmony, or homeostasis, of the activities of thousands of different proteins, whereas aging and diseases result from their disharmony manifested at the levels of cells and tissues. Such disharmony is caused primarily by dysfunction and toxicity of misfolded proteins damag...

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Detalles Bibliográficos
Autor principal: Radman, Miroslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Medical Schools 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230427/
https://www.ncbi.nlm.nih.gov/pubmed/32378382
http://dx.doi.org/10.3325/cmj.2020.61.159
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author Radman, Miroslav
author_facet Radman, Miroslav
author_sort Radman, Miroslav
collection PubMed
description Health can be defined as a harmony, or homeostasis, of the activities of thousands of different proteins, whereas aging and diseases result from their disharmony manifested at the levels of cells and tissues. Such disharmony is caused primarily by dysfunction and toxicity of misfolded proteins damaged by oxidation. This is an overview of key data that inspired new concepts allowing interpretation and integration of the scientific literature on aging and age-related diseases. These concepts suggest strategies for prevention and attenuation of age-related degenerative and malignant diseases mimicking the life of super-centenarians.
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spelling pubmed-72304272020-06-08 Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases Radman, Miroslav Croat Med J Review Health can be defined as a harmony, or homeostasis, of the activities of thousands of different proteins, whereas aging and diseases result from their disharmony manifested at the levels of cells and tissues. Such disharmony is caused primarily by dysfunction and toxicity of misfolded proteins damaged by oxidation. This is an overview of key data that inspired new concepts allowing interpretation and integration of the scientific literature on aging and age-related diseases. These concepts suggest strategies for prevention and attenuation of age-related degenerative and malignant diseases mimicking the life of super-centenarians. Croatian Medical Schools 2020-04 /pmc/articles/PMC7230427/ /pubmed/32378382 http://dx.doi.org/10.3325/cmj.2020.61.159 Text en Copyright © 2020 by the Croatian Medical Journal. All rights reserved. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Radman, Miroslav
Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases
title Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases
title_full Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases
title_fullStr Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases
title_full_unstemmed Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases
title_short Dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases
title_sort dysfunction and toxicity of damaged proteins in the etiology of aging and age-related degenerative and malignant diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230427/
https://www.ncbi.nlm.nih.gov/pubmed/32378382
http://dx.doi.org/10.3325/cmj.2020.61.159
work_keys_str_mv AT radmanmiroslav dysfunctionandtoxicityofdamagedproteinsintheetiologyofagingandagerelateddegenerativeandmalignantdiseases

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