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Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats
Fasting is known to cause physiological changes in the endocrine pancreas, including decreased insulin secretion and increased reactive oxygen species (ROS) production. However, there is no consensus about the long-term effects of intermittent fasting (IF), which can involve up to 24 hours of fastin...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230500/ https://www.ncbi.nlm.nih.gov/pubmed/32283715 http://dx.doi.org/10.3390/nu12041029 |
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author | Munhoz, Ana Cláudia Vilas-Boas, Eloisa Aparecida Panveloski-Costa, Ana Carolina Leite, Jaqueline Santos Moreira Lucena, Camila Ferraz Riva, Patrícia Emilio, Henriette Carpinelli, Angelo R. |
author_facet | Munhoz, Ana Cláudia Vilas-Boas, Eloisa Aparecida Panveloski-Costa, Ana Carolina Leite, Jaqueline Santos Moreira Lucena, Camila Ferraz Riva, Patrícia Emilio, Henriette Carpinelli, Angelo R. |
author_sort | Munhoz, Ana Cláudia |
collection | PubMed |
description | Fasting is known to cause physiological changes in the endocrine pancreas, including decreased insulin secretion and increased reactive oxygen species (ROS) production. However, there is no consensus about the long-term effects of intermittent fasting (IF), which can involve up to 24 hours of fasting interspersed with normal feeding days. In the present study, we analyzed the effects of alternate-day IF for 12 weeks in a developing and healthy organism. Female 30-day-old Wistar rats were randomly divided into two groups: control, with free access to standard rodent chow; and IF, subjected to 24-hour fasts intercalated with 24-hours of free access to the same chow. Alternate-day IF decreased weight gain and food intake. Surprisingly, IF also elevated plasma insulin concentrations, both at baseline and after glucose administration collected during oGTT. After 12 weeks of dietary intervention, pancreatic islets displayed increased ROS production and apoptosis. Despite their lower body weight, IF animals had increased fat reserves and decreased muscle mass. Taken together, these findings suggest that alternate-day IF promote β -cell dysfunction, especially in developing animals. More long-term research is necessary to define the best IF protocol to reduce side effects. |
format | Online Article Text |
id | pubmed-7230500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72305002020-05-22 Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats Munhoz, Ana Cláudia Vilas-Boas, Eloisa Aparecida Panveloski-Costa, Ana Carolina Leite, Jaqueline Santos Moreira Lucena, Camila Ferraz Riva, Patrícia Emilio, Henriette Carpinelli, Angelo R. Nutrients Article Fasting is known to cause physiological changes in the endocrine pancreas, including decreased insulin secretion and increased reactive oxygen species (ROS) production. However, there is no consensus about the long-term effects of intermittent fasting (IF), which can involve up to 24 hours of fasting interspersed with normal feeding days. In the present study, we analyzed the effects of alternate-day IF for 12 weeks in a developing and healthy organism. Female 30-day-old Wistar rats were randomly divided into two groups: control, with free access to standard rodent chow; and IF, subjected to 24-hour fasts intercalated with 24-hours of free access to the same chow. Alternate-day IF decreased weight gain and food intake. Surprisingly, IF also elevated plasma insulin concentrations, both at baseline and after glucose administration collected during oGTT. After 12 weeks of dietary intervention, pancreatic islets displayed increased ROS production and apoptosis. Despite their lower body weight, IF animals had increased fat reserves and decreased muscle mass. Taken together, these findings suggest that alternate-day IF promote β -cell dysfunction, especially in developing animals. More long-term research is necessary to define the best IF protocol to reduce side effects. MDPI 2020-04-09 /pmc/articles/PMC7230500/ /pubmed/32283715 http://dx.doi.org/10.3390/nu12041029 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Munhoz, Ana Cláudia Vilas-Boas, Eloisa Aparecida Panveloski-Costa, Ana Carolina Leite, Jaqueline Santos Moreira Lucena, Camila Ferraz Riva, Patrícia Emilio, Henriette Carpinelli, Angelo R. Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats |
title | Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats |
title_full | Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats |
title_fullStr | Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats |
title_full_unstemmed | Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats |
title_short | Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats |
title_sort | intermittent fasting for twelve weeks leads to increases in fat mass and hyperinsulinemia in young female wistar rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230500/ https://www.ncbi.nlm.nih.gov/pubmed/32283715 http://dx.doi.org/10.3390/nu12041029 |
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