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Drug Toxicity Evaluation Based on Organ-on-a-Chip Technology: A Review

Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in a single device, which facilitates evaluation...

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Autores principales: Cong, Ye, Han, Xiahe, Wang, Youping, Chen, Zongzheng, Lu, Yao, Liu, Tingjiao, Wu, Zhengzhi, Jin, Yu, Luo, Yong, Zhang, Xiuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230535/
https://www.ncbi.nlm.nih.gov/pubmed/32260191
http://dx.doi.org/10.3390/mi11040381
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author Cong, Ye
Han, Xiahe
Wang, Youping
Chen, Zongzheng
Lu, Yao
Liu, Tingjiao
Wu, Zhengzhi
Jin, Yu
Luo, Yong
Zhang, Xiuli
author_facet Cong, Ye
Han, Xiahe
Wang, Youping
Chen, Zongzheng
Lu, Yao
Liu, Tingjiao
Wu, Zhengzhi
Jin, Yu
Luo, Yong
Zhang, Xiuli
author_sort Cong, Ye
collection PubMed
description Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in a single device, which facilitates evaluation of toxicity of drug metabolites. Human organ-on-a-chip has been fabricated and used to assess drug toxicity with data correlation with the clinical trial. In this review, we introduced the microfluidic chip models of liver, kidney, heart, nerve, and other organs and multiple organs, highlighting the application of these models in drug toxicity detection. Some biomarkers of toxic injury that have been used in organ chip platforms or have potential for use on organ chip platforms are summarized. Finally, we discussed the goals and future directions for drug toxicity evaluation based on organ-on-a-chip technology.
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spelling pubmed-72305352020-05-22 Drug Toxicity Evaluation Based on Organ-on-a-Chip Technology: A Review Cong, Ye Han, Xiahe Wang, Youping Chen, Zongzheng Lu, Yao Liu, Tingjiao Wu, Zhengzhi Jin, Yu Luo, Yong Zhang, Xiuli Micromachines (Basel) Review Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in a single device, which facilitates evaluation of toxicity of drug metabolites. Human organ-on-a-chip has been fabricated and used to assess drug toxicity with data correlation with the clinical trial. In this review, we introduced the microfluidic chip models of liver, kidney, heart, nerve, and other organs and multiple organs, highlighting the application of these models in drug toxicity detection. Some biomarkers of toxic injury that have been used in organ chip platforms or have potential for use on organ chip platforms are summarized. Finally, we discussed the goals and future directions for drug toxicity evaluation based on organ-on-a-chip technology. MDPI 2020-04-03 /pmc/articles/PMC7230535/ /pubmed/32260191 http://dx.doi.org/10.3390/mi11040381 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cong, Ye
Han, Xiahe
Wang, Youping
Chen, Zongzheng
Lu, Yao
Liu, Tingjiao
Wu, Zhengzhi
Jin, Yu
Luo, Yong
Zhang, Xiuli
Drug Toxicity Evaluation Based on Organ-on-a-Chip Technology: A Review
title Drug Toxicity Evaluation Based on Organ-on-a-Chip Technology: A Review
title_full Drug Toxicity Evaluation Based on Organ-on-a-Chip Technology: A Review
title_fullStr Drug Toxicity Evaluation Based on Organ-on-a-Chip Technology: A Review
title_full_unstemmed Drug Toxicity Evaluation Based on Organ-on-a-Chip Technology: A Review
title_short Drug Toxicity Evaluation Based on Organ-on-a-Chip Technology: A Review
title_sort drug toxicity evaluation based on organ-on-a-chip technology: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230535/
https://www.ncbi.nlm.nih.gov/pubmed/32260191
http://dx.doi.org/10.3390/mi11040381
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