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Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions

Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are minimally invasive and efficient techniques for the removal of gastrointestinal (GI) mucosal polyps. In both techniques, submucosal injection solutions are necessary for complete effectiveness and safety during the int...

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Autores principales: Moles-Aranda, Cristina, González-Pérez, Raquel, Gallego-Rojo, Francisco Javier, Martínez-Augustin, Olga, Clares-Naveros, Beatriz, Sánchez de Medina, Fermín, Morales-Molina, José Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230585/
https://www.ncbi.nlm.nih.gov/pubmed/32325745
http://dx.doi.org/10.3390/jcm9041162
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author Moles-Aranda, Cristina
González-Pérez, Raquel
Gallego-Rojo, Francisco Javier
Martínez-Augustin, Olga
Clares-Naveros, Beatriz
Sánchez de Medina, Fermín
Morales-Molina, José Antonio
author_facet Moles-Aranda, Cristina
González-Pérez, Raquel
Gallego-Rojo, Francisco Javier
Martínez-Augustin, Olga
Clares-Naveros, Beatriz
Sánchez de Medina, Fermín
Morales-Molina, José Antonio
author_sort Moles-Aranda, Cristina
collection PubMed
description Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are minimally invasive and efficient techniques for the removal of gastrointestinal (GI) mucosal polyps. In both techniques, submucosal injection solutions are necessary for complete effectiveness and safety during the intervention to be obtained. The main objective of this study was to evaluate the efficacy and safety of a new sterile submucosal injection solution for EMR/ESD used within a clinical protocol in patients with intestinal polyps. We carried out a prospective study between 2016 and 2017 with patients who attended the Endoscopy Consultation—Digestive Department of Primary Hospital. Patients were selected for EMR/ESD after the application of clinical protocols. Thirty-six patients were selected (≥ 66 years with comorbidities and risk factors). Lesions were located mainly in the colon. Our solution presented an intestinal lift ≥ 60 min in EMR/ESD and a high expansion of tissue, optimum viscosity, and subsequent complete resorption. The genes S100A9 and TP53 presented an expression increase in the distal regions. TP53 and PCNA were the only genes whose expression was increased in polyp specimens vs. the surrounding tissue at the mRNA level. In EMR/ESD, our solution presented a prolonged effect at the intestinal level during all times of the intervention. Thus, our solution seems be an effective and safe alternative in cases of flat lesions in both techniques.
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spelling pubmed-72305852020-05-22 Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions Moles-Aranda, Cristina González-Pérez, Raquel Gallego-Rojo, Francisco Javier Martínez-Augustin, Olga Clares-Naveros, Beatriz Sánchez de Medina, Fermín Morales-Molina, José Antonio J Clin Med Article Endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are minimally invasive and efficient techniques for the removal of gastrointestinal (GI) mucosal polyps. In both techniques, submucosal injection solutions are necessary for complete effectiveness and safety during the intervention to be obtained. The main objective of this study was to evaluate the efficacy and safety of a new sterile submucosal injection solution for EMR/ESD used within a clinical protocol in patients with intestinal polyps. We carried out a prospective study between 2016 and 2017 with patients who attended the Endoscopy Consultation—Digestive Department of Primary Hospital. Patients were selected for EMR/ESD after the application of clinical protocols. Thirty-six patients were selected (≥ 66 years with comorbidities and risk factors). Lesions were located mainly in the colon. Our solution presented an intestinal lift ≥ 60 min in EMR/ESD and a high expansion of tissue, optimum viscosity, and subsequent complete resorption. The genes S100A9 and TP53 presented an expression increase in the distal regions. TP53 and PCNA were the only genes whose expression was increased in polyp specimens vs. the surrounding tissue at the mRNA level. In EMR/ESD, our solution presented a prolonged effect at the intestinal level during all times of the intervention. Thus, our solution seems be an effective and safe alternative in cases of flat lesions in both techniques. MDPI 2020-04-18 /pmc/articles/PMC7230585/ /pubmed/32325745 http://dx.doi.org/10.3390/jcm9041162 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Moles-Aranda, Cristina
González-Pérez, Raquel
Gallego-Rojo, Francisco Javier
Martínez-Augustin, Olga
Clares-Naveros, Beatriz
Sánchez de Medina, Fermín
Morales-Molina, José Antonio
Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions
title Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions
title_full Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions
title_fullStr Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions
title_full_unstemmed Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions
title_short Efficacy and Safety of a Novel Submucosal Injection Solution for Resection of Gastrointestinal Lesions
title_sort efficacy and safety of a novel submucosal injection solution for resection of gastrointestinal lesions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230585/
https://www.ncbi.nlm.nih.gov/pubmed/32325745
http://dx.doi.org/10.3390/jcm9041162
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